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- Verdrengh, Margareta,1942Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research (author)
IL-1 receptor-associated kinase 1 mediates protection against Staphylococcus aureus infection.
- Article/chapterEnglish2004
Publisher, publication year, extent ...
- Elsevier BV,2004
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/53896
- https://gup.ub.gu.se/publication/53896URI
- https://doi.org/10.1016/j.micinf.2004.08.009DOI
Supplementary language notes
- Language:English
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- SwePubSwePub
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Notes
- The interleukin-1 receptor-associated kinase-1 (IRAK-1) mediates signal transduction from Toll-like/IL-1/IL-18 receptors. Though a critical protective role against Staphylococcus aureus infection has been previously attributed to myeloid differentiation factor 88 (MyD88) and IRAK-4, both also involved in TLR/IL-1/IL-18 signaling, the role of IRAK-1 is unknown. IRAK-1-deficient (IRAK-1-/-) and wild-type mice were inoculated i.v. with 2 x 10(7) or 1 x 10(6) S. aureus per mouse to evaluate the role of IRAK-1 in S. aureus sepsis. Since IRAK-1 transduces IL-1R signals, IL-1R-/- mice were also included in experiments. IRAK-1-/- mice are susceptible to a high dose of S. aureus compared to wild-type controls. In contrast to the high mortality and extensive weight loss seen in IL-1R-deficient mice in response to 1 x 10(6) S. aureus, IRAK-1-/- mice are resistant to this low dose of S. aureus. Thus IRAK-1 plays an important role in the host response to staphylococcal sepsis.
Subject headings and genre
- Animals
- Bacteremia
- Blood
- microbiology
- Body Weight
- Colony Count
- Microbial
- Disease Susceptibility
- Female
- Immunity
- Natural
- Interleukin-1
- blood
- Interleukin-1 Receptor-Associated Kinases
- Interleukin-18
- blood
- Interleukin-18 Receptor alpha Subunit
- Kidney
- microbiology
- Male
- Membrane Glycoproteins
- metabolism
- Mice
- Mice
- Inbred C57BL
- Mice
- Knockout
- Protein Kinases
- genetics
- metabolism
- Receptors
- Cell Surface
- metabolism
- Receptors
- Interleukin
- metabolism
- Receptors
- Interleukin-1
- genetics
- metabolism
- Receptors
- Interleukin-18
- Signal Transduction
- Staphylococcal Infections
- enzymology
- immunology
- Staphylococcus aureus
- immunology
- Survival Analysis
- Toll-Like Receptors
Added entries (persons, corporate bodies, meetings, titles ...)
- Thomas, James A (author)
- Hultgren, Olof H.,1970Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk immunologi,Institute of Laboratory Medicine, Dept of Clinical Immunology(Swepub:gu)xhulol (author)
- Göteborgs universitetInstitutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning (creator_code:org_t)
Related titles
- In:Microbes and infection / Institut Pasteur: Elsevier BV6:14, s. 1268-721286-4579
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