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Safety and immunoge...
Safety and immunogenicity of a reformulated Vietnamese bivalent killed, whole-cell, oral cholera vaccine in adults.
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Anh, Dang Duc (author)
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Canh, Do Gia (author)
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Lopez, Anna Lena (author)
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Thiem, Vu Dinh (author)
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Long, Phan Thi (author)
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Son, Nguyen Hong (author)
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Deen, Jacqueline (author)
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von Seidlein, Lorenz (author)
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Carbis, Rodney (author)
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Han, Seung Hyun (author)
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Shin, Seong Hye (author)
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- Attridge, Stephen, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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- Holmgren, Jan, 1944 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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Clemens, John (author)
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- English.
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In: Vaccine. - : Elsevier BV. - 0264-410X. ; 25:6, s. 1149-55
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https://doi.org/10.1...
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Abstract
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- Vietnam currently produces an orally administered, bivalent (O1 and O139) killed whole-cell vaccine and is the only country in the world with endemic cholera to use an oral cholera vaccine in public health practice. In order to allow international use, the vaccine had to be reformulated to meet World Health Organization (WHO) requirements. We performed a randomized, placebo controlled, safety and immunogenicity studies of this reformulated vaccine among Vietnamese adults. One hundred and forty-four subjects received the two-dose regimen and 143 had two blood samples obtained for analysis. We found that this reformulated oral killed whole-cell cholera vaccine was safe, well tolerated and highly immunogenic.
Keyword
- Administration
- Oral
- Adolescent
- Adult
- Cholera
- immunology
- microbiology
- prevention & control
- Cholera Vaccines
- administration & dosage
- adverse effects
- immunology
- Double-Blind Method
- Female
- Humans
- Male
- Vaccines
- Inactivated
- administration & dosage
- adverse effects
- immunology
- Vibrio cholerae O1
- immunology
- Vibrio cholerae O139
- immunology
- Vietnam
Publication and Content Type
- ref (subject category)
- art (subject category)
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Vaccine
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- By the author/editor
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Anh, Dang Duc
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Canh, Do Gia
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Lopez, Anna Lena
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Thiem, Vu Dinh
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Long, Phan Thi
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Son, Nguyen Hong
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show more...
-
Deen, Jacqueline
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von Seidlein, Lo ...
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Carbis, Rodney
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Han, Seung Hyun
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Shin, Seong Hye
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Attridge, Stephe ...
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Holmgren, Jan, 1 ...
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Clemens, John
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show less...
- Articles in the publication
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Vaccine
- By the university
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University of Gothenburg