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Dextran sulfate sod...
Dextran sulfate sodium-induced colitis generates a transient thymic involution--impact on thymocyte subsets.
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- Fredin, Maria Fritsch, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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- Elgbratt, Kristina, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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Svensson, D (author)
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Jansson, L (author)
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Melgar, S (author)
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- Hultgren-Hörnquist, Elisabeth, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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(creator_code:org_t)
- Wiley, 2007
- 2007
- English.
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In: Scandinavian journal of immunology. - : Wiley. - 0300-9475 .- 1365-3083. ; 65:5, s. 421-9
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Abstract
Subject headings
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- One of the most widely used animal models for inflammatory bowel disease (IBD) is the dextran sulfate sodium (DSS)-induced colitis. We have previously reported that 5 days administration of DSS in C57Bl/6J mice induces a colonic inflammation that progresses into chronicity after DSS removal, whereas in BALB/cJ mice the inflammation resolves within 4 weeks post-DSS. Here we show that both thymic size and thymocyte numbers dramatically decreased in the acute phase of inflammation in C57Bl/6 mice, 7 days after DSS withdrawal. Mature, CD4(+) and CD8(+) single positive (SP) CD69(lo) CD62L(hi) thymocytes were enriched in these mice, accompanied by a major decrease in the number of immature double positive (DP) thymocytes. However, the different maturation stages within the DP thymocyte subset were unchanged between healthy and inflamed C57Bl/6J mice. Interestingly, as the inflammation progressed into the chronic phase, the thymus recovered and 2 weeks after the acute inflammatory phase all the thymic parameters investigated in this study were restored to normal. In contrast, BALB/cJ mice only develop mild thymic alterations. Nevertheless, we found that within the double negative (DN) thymocytes an increased frequency and also total numbers of CD44(+) CD25(-) (DN1) cells correlated with the severity of colitis, and that the frequency of CD44(-) CD25(-) (DN4) thymocytes decreased proportionally in the acute phase in BALB/cJ mice. Our observations suggest that the thymic effects are intimately connected to the intestinal inflammatory response in colitis regardless of the inflammatory stimuli.
Keyword
- Acute Disease
- Animals
- Cell Differentiation
- immunology
- Chronic Disease
- Colitis
- chemically induced
- immunology
- pathology
- Dextran Sulfate
- administration & dosage
- Immunophenotyping
- Lymphocyte Subsets
- drug effects
- immunology
- pathology
- Lymphopenia
- immunology
- pathology
- Mice
- Mice
- Inbred BALB C
- Mice
- Inbred C57BL
- Severity of Illness Index
- T-Lymphocyte Subsets
- drug effects
- immunology
- pathology
- Thymus Gland
- drug effects
- immunology
- pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
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