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Long-term treatment...
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Taheri-Kadkhoda, Zahra,1969Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
(author)
Long-term treatment results for nasopharyngeal carcinoma: the Sahlgrenska University Hospital experience.
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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2009-07-08
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Informa UK Limited,2007
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/54327
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https://gup.ub.gu.se/publication/54327URI
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https://doi.org/10.1080/02841860601016062DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Nasopharyngeal carcinoma (NPC) is a rare disease in Sweden. For evaluation of the treatment outcomes in our NPC patients, 52 new cases that were referred to our department between 1991 and 2002 were retrospectively analysed. Tumor stage, according to the 1997 AJCC staging system, was I in five, II in ten, III in 12 and IV in 25 patients. Majority of the patients (87%) had World Health Organization type II-III tumors. Neoadjuvant chemotherapy was delivered in 33 patients. Thirty-two patients received hyperfractionated accelerated radiation therapy with a median dose of 64.6Gy (1.7Gy/fr bid). Conventional external irradiation with a median dose of 66Gy (2Gy/fr) was delivered to 18 patients. An intracavitary brachy-boost of 4.5-12Gy was delivered to 40 patients. Two patients were excluded from the analysis due to treatment refusal. For the patients with tumor stages I-IVB, the 5-year disease-free and overall survival rates were 61% and 55%, respectively. The 5-year local, regional, and distant relapse-free survival rates were 70%, 92% and 77%, respectively. The most frequent late side effects were xerostomia (98%), otitis (70%) and hearing deterioration (64%). Our data suggest that optimization of the treatment outcomes in NPC patients requires implementation of new therapeutic strategies.
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Björk-Eriksson, Thomas,1960Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xbjoth
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Johansson, Karl-AxelGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Mercke, Claes,1941Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xmercl
(author)
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Göteborgs universitetInstitutionen för kliniska vetenskaper
(creator_code:org_t)
Related titles
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In:Acta oncologica (Stockholm, Sweden): Informa UK Limited46:6, s. 817-270284-186X1651-226X
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