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The bradykinin BK2 ...
The bradykinin BK2 receptor mediates angiotensin II receptor type 2 stimulated rat duodenal mucosal alkaline secretion.
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- Ewert, Sara, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för gastroforskning,Institute of Surgical Sciences, Department of Gastro Research
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- Johansson, Berndt, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för gastroforskning,Institute of Surgical Sciences, Department of Gastro Research
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- Holm, Mathias, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för gastroforskning,Institute of Surgical Sciences, Department of Gastro Research
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- Helander, Herbert F, 1935 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för gastroforskning,Institute of Surgical Sciences, Department of Gastro Research
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- Fändriks, Lars, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för gastroforskning,Institute of Surgical Sciences, Department of Gastro Research
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(creator_code:org_t)
- 2003
- 2003
- English.
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In: BMC physiology. - 1472-6793. ; 3
- Related links:
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Abstract
Subject headings
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- BACKGROUND: This study investigates bradykinin and nitric oxide as potential mediators of AT2-receptor-stimulated duodenal mucosal alkaline secretion. Duodenal mucosal alkaline secretion was measured in methohexital- and alpha-chloralose-anaesthetised rats by means of in situ pH-stat titration. Immunohistochemistry and Western blot were used to identify the BK2 receptors. RESULTS: The AT2 receptor agonist CGP42112A (0.1 microg kg(-1) min(-1)) administered intravenously increased the duodenal mucosal alkaline secretion by approximately 50 %. This increase was sensitive to the selective BK2 receptor blocker HOE140 (100 ng/kg i.v.), but not to luminal administration of the NOS blocker L-NAME (0.3 mM). Mean arterial pressure did not differ between groups during the procedures. Immunohistochemistry showed a distinct staining of the crypt epithelium and a moderate staining of basal cytoplasm in villus enterocytes. CONCLUSION: The results suggest that the AT2-receptor-stimulated alkaline secretion is mediated via BK2 receptors located in the duodenal cryptal mucosal epithelium.
Keyword
- Animals
- Blood Pressure
- physiology
- Duodenum
- blood supply
- chemistry
- physiology
- secretion
- Fasting
- physiology
- Hydrogen-Ion Concentration
- Intestinal Mucosa
- blood supply
- chemistry
- physiology
- secretion
- Intestinal Secretions
- chemistry
- physiology
- Male
- Rats
- Rats
- Sprague-Dawley
- Receptor
- Angiotensin
- Type 2
- physiology
- Receptor
- Bradykinin B2
- metabolism
- physiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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