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Effect of oxybenzon...
Effect of oxybenzone on PGE2-production in vitro and on plaque and gingivitis in vivo.
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- Jannesson, Lillemor (author)
- Kristianstad University
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- Birkhed, Dowen, 1946 (author)
- Gothenburg University,Göteborgs universitet,Odontologiska institutionen, Avdelningen för cariologi,Institute of Odontology, Department of Cariology
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Scherl, Dale (author)
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Gaffar, Abdul (author)
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- Renvert, Stefan (author)
- Kristianstad University
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(creator_code:org_t)
- Wiley, 2004
- 2004
- English.
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In: Journal of clinical periodontology. - : Wiley. - 0303-6979 .- 1600-051X. ; 31:2, s. 91-4
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Abstract
Subject headings
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- OBJECTIVES: To study the effect of oxybenzone on prostaglandin E2 (PGE2) production in cell culture and to evaluate the effect of an oxybenzone-containing dentifrice on plaque and gingivitis in a 6-week clinical trial. MATERIAL AND METHODS: Human embryo palatal mesenchyme (HEPM) cells were used for testing the inhibition of IL-1beta-stimulated PGE2-production in vitro by different concentrations of oxybenzone. For the in vivo study, a total of 66 individuals with a Quigley & Hein plaque index of at least 1.5 and an Ainamo & Bay gingival index of at least 0.2 were included in a double-blind clinical trial with two cells and a parallel design. Two compositions of fluoride dentifrice were used, one with the addition of 0.5% oxybenzone, and one without. Plaque and gingival index were obtained at three time points: (1) at baseline, (2) after 3 weeks, and (3) after 6 weeks. RESULTS: A dose-dependent inhibition of PGE2-production was found in the HEPM cell culture following oxybenzone exposure. In the clinical trial, a 25% reduction of gingival index was observed in the oxybenzone group (p<0.001) after 6 weeks as compared with 2% for the placebo group. CONCLUSIONS: These findings indicate that PGE2-production is reduced by oxybenzone in vitro and that the use of oxybenzone in a dentifrice reduces gingivitis in vivo.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Keyword
- Adolescent
- Adult
- Aged
- Benzophenones
- pharmacology
- therapeutic use
- Cell Culture Techniques
- Dental Plaque
- prevention & control
- Dental Plaque Index
- Dentifrices
- therapeutic use
- Dinoprostone
- antagonists & inhibitors
- Dose-Response Relationship
- Drug
- Double-Blind Method
- Follow-Up Studies
- Gingivitis
- prevention & control
- Humans
- Interleukin-1
- pharmacology
- Mesoderm
- drug effects
- Middle Aged
- Periodontal Index
- Placebos
Publication and Content Type
- ref (subject category)
- art (subject category)
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