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Antisecretory facto...
Antisecretory factor modulates GABAergic transmission in the rat hippocampus.
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- Kim, Malin (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology
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- Wasling, Pontus, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology
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- Xiao, Min-Yi, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology
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- Jennische, Eva, 1949 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för anatomi och cellbiologi,Institute of Anatomy and Cell Biology
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- Lange, Stefan, 1948 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk bakteriologi,Institute of Laboratory Medicine, Dept of Clinical Bacteriology
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- Hanse, Eric, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology
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(creator_code:org_t)
- Elsevier BV, 2005
- 2005
- English.
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In: Regulatory peptides. - : Elsevier BV. - 0167-0115. ; 129:1-3, s. 109-18
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Antisecretory Factor (AF) is a protein that has been implicated in the suppression of intestinal hypersecretion and inflammation. Intestinal secretion and inflammation are partly under local and central neural control raising the possibility that AF might exert its action by modulating neural signaling. In the present study we have investigated whether AF can modulate central synaptic transmission. Evoked glutamatergic and GABAergic synaptic transmissions were investigated using extracellular recordings in the CA1 region of hippocampal slices from adult rats. AF (0.5 microg/ml) suppressed GABA(A)-mediated synaptic transmission by about 40% while having no effect on glutamatergic transmission. Per oral administration of cholera toxin as well as feeding of rats with a diet containing hydrothermally processed cereals, known to upregulate endogenous AF plasma activity, mimicked the effect of exogenously administered AF on hippocampal GABAergic transmission. Our results identify AF as a neuromodulator and further raise the possibility that the hippocampus and AF are involved in a gut-brain loop controlling intestinal secretion and inflammation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Animals
- Hippocampus
- cytology
- physiology
- Male
- Membrane Potentials
- drug effects
- physiology
- Neuropeptides
- pharmacology
- Organ Culture Techniques
- Rats
- Rats
- Sprague-Dawley
- Synaptic Transmission
- drug effects
- physiology
- gamma-Aminobutyric Acid
- metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kim, Malin
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Wasling, Pontus, ...
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Xiao, Min-Yi, 19 ...
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Jennische, Eva, ...
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Lange, Stefan, 1 ...
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Hanse, Eric, 196 ...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
- Articles in the publication
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Regulatory pepti ...
- By the university
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University of Gothenburg