Placebo-controlled trial comparing intermittent and continuous paroxetine in premenstrual dysphoric disorder.

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Landén, Mikael,1966Karolinska Institutet (author)

Placebo-controlled trial comparing intermittent and continuous paroxetine in premenstrual dysphoric disorder.

Article/chapterEnglish2007

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2006-10-11
Springer Science and Business Media LLC,2007

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LIBRIS-ID:oai:gup.ub.gu.se/55571
https://gup.ub.gu.se/publication/55571URI
https://doi.org/10.1038/sj.npp.1301216DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:13889113URI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Serotonin reuptake inhibitors (SRIs) do not have to be administered continuously to be effective for premenstrual dysphoric disorder (PMDD), but can be given during luteal phases only. This is of practical importance, but also of theoretical interest since it suggests that the onset of action of SRIs is shorter in PMDD than in, for example depression. In this study, both continuous and intermittent SRI administration was compared with placebo, with the special purpose of analyzing if different PMDD symptoms respond differently depending on the treatment regimen. To this end, women meeting slightly modified DSM-IV criteria for PMDD (mean+/-SD age, 37+/-6.3 years) were treated for three menstrual cycles with paroxetine continuously, paroxetine during the luteal phase only, or placebo, the population completing at least one treatment cycle comprising 55-56 subjects per group. Continuous treatment with paroxetine reduced premenstrual symptoms effectively with a response rate of 85%. The effect size was highest for irritability (1.4) and lowest for lack of energy (0.5). Intermittent treatment was as effective as continuous treatment in reducing irritability, affect lability, and mood swings, but had a somewhat weaker effect on depressed mood and somatic symptoms. The study indicates that the response rate when treating PMDD with SRIs is high, and that irritability is a key target symptom. Symptoms such as irritability, affect lability, and mood swings appear to be more inclined to respond rapidly to SRIs, enabling intermittent treatment, than are, for example, the somatic symptoms.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
Adult
Disability Evaluation
Double-Blind Method
Drug Administration Schedule
Female
Humans
Pain Measurement
methods
Paroxetine
therapeutic use
Placebos
Premenstrual Syndrome
drug therapy
psychology
Serotonin Uptake Inhibitors
therapeutic use
Treatment Outcome

Added entries (persons, corporate bodies, meetings, titles ...)

Nissbrandt, Hans,1952Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology(Swepub:gu)xnisha (author)
Allgulander, ChristerKarolinska Institutet (author)
Sörvik, Karin (author)
Ysander, Christina (author)
Eriksson, Elias,1956Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology(Swepub:gu)xereli (author)
Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi, sektionen för farmakologi (creator_code:org_t)

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In:Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology: Springer Science and Business Media LLC32:1, s. 153-610893-133X
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