Search: onr:"swepub:oai:gup.ub.gu.se/56424" >
Cyclooxygenase-2 po...
-
Håkansson, Anna,1978Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology
(author)
Cyclooxygenase-2 polymorphisms in Parkinson's disease.
- Article/chapterEnglish2007
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/56424
-
https://gup.ub.gu.se/publication/56424URI
-
https://doi.org/10.1002/ajmg.b.30449DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:11949URI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Accumulating evidence indicate that cyclooxygenase-2 (COX-2) is of pathophysiological importance for the neurodegeneration in Parkinson's disease (PD). For example, in a large epidemiological study, use of NSAIDs was associated with a lower risk of PD. Genetic variants of the COX-2 gene might therefore influence the risk of developing the disease. The genotype distribution of four common single nucleotide polymorphisms (SNPs) in the COX-2 gene (rs689466:A496G, rs20417:G926C, rs5277:G3050C, rs5275:C8473T) was analyzed in PD patients and control subjects in a Swedish population. No differences could be seen between the PD-patient and controls regarding the A496G, G926C, and G3050C SNPs, but the allele frequency of the C8473T SNP was found to differ when male patients were compared to controls (P = 0.007). In females no difference could be seen between PD-patients and controls. In conclusion, the results suggest a possible influence of the COX-2 C8473T SNP in PD, although it only seems to be of importance in men.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Bergman, Olle,1978Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology(Swepub:gu)xbeoll
(author)
-
Chrapkowska, CeciliaKarolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology
(author)
-
Westberg, Lars,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology(Swepub:gu)xwelar
(author)
-
Belin, Andrea Carmine
(author)
-
Sydow, OlofKarolinska Institutet
(author)
-
Johnels, Bo,1940Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation(Swepub:gu)xjoboz
(author)
-
Olson, LarsKarolinska Institutet
(author)
-
Holmberg, BjörnGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation(Swepub:gu)xhobjo
(author)
-
Nissbrandt, Hans,1952Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology(Swepub:gu)xnisha
(author)
-
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för farmakologi
(creator_code:org_t)
Related titles
-
In:American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics: Wiley144:3, s. 367-91552-4841
-
In:American Journal of Medical Genetics Part B: Neuropsychiatric Genetics: Wiley144:3, s. 367-91552-485X
Internet link
Find in a library
To the university's database
- By the author/editor
-
Håkansson, Anna, ...
-
Bergman, Olle, 1 ...
-
Chrapkowska, Cec ...
-
Westberg, Lars, ...
-
Belin, Andrea Ca ...
-
Sydow, Olof
-
show more...
-
Johnels, Bo, 194 ...
-
Olson, Lars
-
Holmberg, Björn
-
Nissbrandt, Hans ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Physiology
- Articles in the publication
-
American journal ...
-
American Journal ...
- By the university
-
University of Gothenburg
-
Karolinska Institutet