Bronchial mucosal mast cells in asymptomatic smokers relation to structure, lung function and emphysema

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:gup.ub.gu.se/57187" > Bronchial mucosal m...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Ekberg-Jansson, Ann,1960Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine (author)

Bronchial mucosal mast cells in asymptomatic smokers relation to structure, lung function and emphysema

Article/chapterEnglish2005

Publisher, publication year, extent ...

Elsevier BV,2005

Numbers

LIBRIS-ID:oai:gup.ub.gu.se/57187
https://gup.ub.gu.se/publication/57187URI
https://doi.org/10.1016/j.rmed.2004.05.013DOI
https://lup.lub.lu.se/record/255552URI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-73017URI

Supplementary language notes

Language:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

The pathologic mechanisms of chronic obstructive pulmonary disease (COPD) most certainly involves neutrophil granulocytes, cytotoxic T-cells, macophages and mast cells. The aim of this study was to investigate the relation between the number of mast cells in different compartments in bronchial biopsies of central proximal airways to structural changes, lung function tests and emphysema detected by high resolution computed tomography (HRCT). Twenty nine asymptomatic smoking and 16 never-smoking men from a population study were recruited. Central bronchial biopsies were stained to identify mast cells by immunohistochemistry. The number of mast cells in the epithelium, lamina propria and smooth muscle as well as epithelial integrity and thickness of the tenascin and laminin layer were determined. Smokers had increased numbers of mast cells in all compartments (P<0.001). Structural changes were correlated to mast cell numbers with the closest associations to mast cell numbers in the smooth muscle [epithelial integrity (R(S)=-0.48, P=0.008), laminin layer (R(S)=0.63, P=0.0002), tenascin layer (R(S)=0.40, P=0.03)]. Similar correlations between mast cells and lung function tests were seen [functional residual capacity (FRC) (R(S)=0.60, P=0.0006), total lung capacity (TLC) (R(S)=0.44, P=0.02) and residual volume (RV) (R(S)=0.41, P=0.03)]. No correlations could be detected between mast cells and FEV1 or to emphysema. Smoking is associated with an increase of mast cells in all compartments of the bronchial mucosa, including smooth muscle, and this is related to altered airway structure and function.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
Aged
Biopsy
Bronchi/*pathology
Cell Count
Humans
Male
Mast Cells/*pathology
Muscle
Smooth/pathology
Pulmonary Emphysema/etiology/*pathology/physiopathology/radiography
Respiratory Mechanics
Respiratory Mucosa/pathology
Smoking/adverse effects/*pathology/physiopathology
Tomography
X-Ray Computed
high-resolution computed
lung function
chronic bronchitis
mast cells
tomography
respiratory symptoms
Aged
MEDICINE

Added entries (persons, corporate bodies, meetings, titles ...)

Amin, KawaUppsala universitet,Institutionen för medicinska vetenskaper,Inflammation(Swepub:uu)kawaamin (author)
Bake, Björn,1939Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi,Institute of Internal Medicine, Dept of Respiratory Medicine/Allergology(Swepub:gu)xbakbj (author)
Rosengren, Annika,1951Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine(Swepub:gu)xrosan (author)
Tylén, Ulf,1938Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för radiologi,Institute of Selected Clinical Sciences, Department of Radiology(Swepub:gu)xtyleu (author)
Venge, PerUppsala universitet,Institutionen för medicinska vetenskaper,Inflammation(Swepub:uu)pervenge (author)
Löfdahl, Claes-GöranLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)lung-cgl (author)
Göteborgs universitetInstitutionen för invärtesmedicin, Avdelningen för internmedicin (creator_code:org_t)

Related titles

In:Respir Med: Elsevier BV99:1, s. 75-830954-61111532-3064

Internet link

Find in a library

Respir Med (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Ekberg-Jansson, ...; Amin, Kawa; Bake, Björn, 193 ...; Rosengren, Annik ...; Tylén, Ulf, 1938; Venge, Per; show more...; Löfdahl, Claes-G ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Respiratory Medi ...

Articles in the publication: Respir Med

By the university: University of Gothenburg; Lund University; Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se