Lifestyle modification improves risk factors in type 2 diabetes relatives.

Brekke, Hilde Kristin, 1972 (author): Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för klinisk näringslära,Institute of Internal Medicine, Dept of Clinical Nutrition

Arvidsson Lenner, Ragnhild, 1938 (author): Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för klinisk näringslära,Institute of Internal Medicine, Dept of Clinical Nutrition

Taskinen, M. R. (author)

Månsson, Jan-Eric, 1946 (author): Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för laborativ neurovetenskap,Institute of Clinical Neurosciences, Section of Experimental Neuroscience

Funahashi, Tohru (author)

Matsuzawa, Yuji (author)

Jansson, Per-Anders, 1961 (author): Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine

(creator_code:org_t)

Elsevier BV, 2005
2005
English.
In: Diabetes research and clinical practice. - : Elsevier BV. - 0168-8227. ; 68:1, s. 18-28

Related links:: https://gup.ub.gu.se...; show more...; https://doi.org/10.1...; show less...

Abstract Subject headings

AIMS: To investigate the short-term (16 weeks) effect of lifestyle intervention on insulin sensitivity, anthropometric and metabolic variables in non-diabetic first-degree relatives of type 2 diabetic patients (FDR). METHODS: Seventy-seven (49 male, 28 female) FDR were allocated to one of three groups, diet (D-group; n = 25), diet and exercise (DE-group; n = 30) or control group (C-group; n = 22). Lifestyle counselling was based on current nutrition recommendations, including increased intake of fatty fish and low glycaemic index foods. Group counselling was given on two occasions with follow-up through telephone interviews every 10 days. Assessments included insulin sensitivity index (Si), anthropometry, lipid parameters, circulating leptin and adiponectin levels. RESULTS: The D-group reduced total cholesterol (-0.31 mmol/l, P = 0.024), LDL cholesterol (-0.22 mmol/l, P = 0.021) and apolipoprotein B (-9.5 mg/dl, P = 0.009) levels, whereas the DE-group decreased body weight (-2.1%, P = 0.030) and waist circumference (-3.0 cm, P < 0.001) versus controls. A 13% reduction in fasting insulin was observed in the DE-group, but no significant improvement in Si in D-group or DE-group was observed. A subgroup, adherent to diet and who increased exercise, significantly improved Si and lipid profile. CONCLUSIONS: The improved metabolic risk profile in FDR suggests that lifestyle changes can be effective in individuals at high risk to develop type 2 diabetes and cardiovascular disease.

By the author/editor: Brekke, Hilde Kr ...; Arvidsson Lenner ...; Taskinen, M. R.; Månsson, Jan-Eri ...; Funahashi, Tohru; Matsuzawa, Yuji; show more...; Jansson, Per-And ...; show less...

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