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Association between...
Association between a functional polymorphism in the progesterone receptor gene and panic disorder in women.
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- Ho, Hoi-Por, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology,University of Gothenburg
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- Westberg, Lars, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology,University of Gothenburg
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- Annerbrink, Kristina, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology,University of Gothenburg
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- Olsson, Marie, 1971 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology,University of Gothenburg
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- Melke, Jonas, 1971 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology,University of Gothenburg
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- Nilsson, Staffan, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematisk statistik,Department of Mathematical Statistics,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology
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- Baghaei, Fariba, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi,Institute of Internal Medicine, Dept of Respiratory Medicine/Allergology,University of Gothenburg
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- Rosmond, Roland, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi,Institute of Internal Medicine, Dept of Respiratory Medicine/Allergology,University of Gothenburg
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- Holm, Göran, 1942 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi,Institute of Internal Medicine, Dept of Respiratory Medicine/Allergology,University of Gothenburg
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- Björntorp, Per, 1931 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi,Institute of Internal Medicine, Dept of Respiratory Medicine/Allergology,University of Gothenburg
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- Andersch, Sven, 1939 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences,University of Gothenburg
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- Allgulander, Christer (author)
- Karolinska Institutet
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- Eriksson, Elias, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institutionen för klinisk neurovetenskap,Institute of Physiology and Pharmacology, Dept of Pharmacology,Institute of Clinical Neurosciences,University of Gothenburg
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(creator_code:org_t)
- Elsevier BV, 2004
- 2004
- English.
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In: Psychoneuroendocrinology. - : Elsevier BV. - 0306-4530. ; 58:2, s. 109-110
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Abstract
Subject headings
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- Although genetic factors are known to be important risk factors for panic disorder there is as yet no conclusive data regarding specific gene variants. Prompted by evidence supporting progesterone to influence the pathophysiology of panic disorder, polymorphisms in the progesterone receptor gene, a single nucleotide polymorphism (G331A) and an insertion/deletion polymorphism (PROGINS) were investigated in 72 patients with panic disorder and 452 controls. The frequency of the A-allele of the G331A polymorphism was higher in panic disorder patients than in controls (p = 0.01). When male and female patients were analyzed separately, the association was observed in female patients only (p = 0.0009), with an odds ratio of 3.5. No differences between groups were observed for the PROGINS polymorphism. In conclusion, these data suggest that the G331A polymorphism in the progesterone receptor gene may influence the risk for panic disorder in women.
Keyword
- Chromosomes
- Human
- Pair 11
- genetics
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Humans
- Male
- Panic Disorder
- genetics
- Polymorphism
- Single Nucleotide
- genetics
- Receptors
- Progesterone
- genetics
- Risk Factors
- Sex Factors
- Genetic Predisposition to Disease
Publication and Content Type
- ref (subject category)
- art (subject category)
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Ho, Hoi-Por, 196 ...
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Westberg, Lars, ...
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Annerbrink, Kris ...
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Olsson, Marie, 1 ...
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Melke, Jonas, 19 ...
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Nilsson, Staffan ...
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Baghaei, Fariba, ...
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Rosmond, Roland, ...
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Holm, Göran, 194 ...
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Björntorp, Per, ...
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Andersch, Sven, ...
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Allgulander, Chr ...
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Eriksson, Elias, ...
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Psychoneuroendoc ...
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NORDIC JOURNAL O ...
- By the university
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University of Gothenburg
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Chalmers University of Technology
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Karolinska Institutet