Acute psychological stress raises plasma ghrelin in the rat.

Kristensson, E (author)

Sundqvist, Monika, 1976 (author): Gothenburg University,Göteborgs universitet,Zoologiska institutionen,Department of Zoology

Astin, M (author)

Kjerling, M (author)

Mattsson, H (author)

de la Cour, Charlotta (author): Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine

Håkanson, Rolf (author): Lund University,Lunds universitet,Drug Target Discovery,Forskargrupper vid Lunds universitet,Lund University Research Groups

Lindstrom, E (author)

(creator_code:org_t)

Elsevier BV, 2006
2006
English.
In: Regulatory Peptides. - : Elsevier BV. - 0167-0115 .- 1873-1686. ; 134:2-3, s. 114-117

Related links:: http://dx.doi.org/10...; show more...; https://gup.ub.gu.se...; https://doi.org/10.1...; https://lup.lub.lu.s...; show less...

Abstract Subject headings

Ghrelin is produced by the A-like cells of the stomach and mobilized by food deprivation. It was reported recently that acute psychological stress increases ghrelin gene expression in rat oxyntic mucosa. The aim of this study was to examine the effect of such stress on circulating ghrelin levels. To this end, we measured plasma ghrelin in Wistar Kyoto (WKY) rats (a high-anxiety strain) and Sprague–Dawley (SPD) rats (a low-anxiety strain), exposed to water avoidance stress for 60 min. Blood was collected before and after the stress. Acute stress increased the plasma ACTH concentration not, vert, similar5-fold (p < 0.01) in both strains of rats, while plasma ghrelin increased by 85% (p < 0.01) in the SPD rats and by 40% (p < 0.001) in the WKY rats. Ghrelin levels after acute stress were higher (p < 0.05) in the SPD rats than in the WKY rats. Sham stress did not affect plasma ghrelin. We conclude that acute psychological stress mobilizes ghrelin and that the SPD rats respond with a higher plasma ghrelin concentration than the WKY rats.

NATURVETENSKAP -- Biologi -- Zoologi (hsv//swe)
NATURAL SCIENCES -- Biological Sciences -- Zoology (hsv//eng)
NATURVETENSKAP -- Biologi (hsv//swe)
NATURAL SCIENCES -- Biological Sciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

By the author/editor: Kristensson, E; Sundqvist, Monik ...; Astin, M; Kjerling, M; Mattsson, H; de la Cour, Char ...; show more...; Håkanson, Rolf; Lindstrom, E; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

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