The AST/ALT ratio as an indicator of cirrhosis in patients with PBC.

Nyblom, Helena,1968Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine (author)

OBJECTIVES: A non-invasive, simple and non-expensive test to predict cirrhosis would be highly desirable. The aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio has been proven to be such an indicator of cirrhosis in alcoholic liver disease, hepatitis C. AIM: To test whether the AST/ALT ratio is a marker of cirrhosis also in patients with primary biliary cirrhosis (PBC). METHODS: The study consisted of 160 patients. In 126 patients, we had clinical and laboratory data at the time of diagnosis and follow-up with outcome: liver-related death, liver transplantation and survival. In 121 patients, we had laboratory data and liver histology. RESULTS: We found that the AST/ALT ratio was significantly higher in cirrhotic patients than in non-cirrhotic patients. A high AST/ALT ratio was significantly associated with esophageal varices and ascites. In a multivariate analysis, bilirubin and ALP were predictors of poor prognosis. CONCLUSION: The AST/ALT ratio seems to be of clinical value as a hint to the diagnosis of cirrhosis in patients with PBC but not as a prognostic factor.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
Adult
Aged
Alanine Transaminase
blood
Aspartate Aminotransferases
blood
Biological Markers
Case-Control Studies
Disease Progression
Female
Humans
Liver Cirrhosis
blood
etiology
physiopathology
Liver Cirrhosis
Biliary
blood
physiopathology
Liver Function Tests
Male
Middle Aged
Predictive Value of Tests
Prognosis
Sensitivity and Specificity
MEDICINE

Björnsson, Einar,1958Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xbjoei (author)
Simrén, Magnus,1966Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xsimrm (author)
Aldenborg, Frank,1945Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology(Swepub:gu)xaldfr (author)
Almer, Sven,1953-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Gastroenterologi och hepatologi,Endokrin- och magtarmmedicinska kliniken US(Swepub:liu)sveal38 (author)
Olsson, Rolf,1936Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xolrol (author)
Göteborgs universitetInstitutionen för medicin, avdelningen för invärtesmedicin (creator_code:org_t)

In:Liver international : official journal of the International Association for the Study of the Liver: Wiley26:7, s. 840-51478-32231478-3231
In:Liver International: Wiley26:7, s. 840-51478-3231

By the author/editor: Nyblom, Helena, ...; Björnsson, Einar ...; Simrén, Magnus, ...; Aldenborg, Frank ...; Almer, Sven, 195 ...; Olsson, Rolf, 19 ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Gastroenterology ...

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