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Small intestinal ba...
Small intestinal bacterial overgrowth in patients with irritable bowel syndrome.
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- Posserud, Iris, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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- Stotzer, Per-Ove, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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- Björnsson, Einar, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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- Abrahamsson, Hasse, 1943 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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- Simrén, Magnus, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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(creator_code:org_t)
- BMJ, 2007
- 2007
- English.
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In: Gut. - : BMJ. - 0017-5749. ; 56:6, s. 802-8
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Abstract
Subject headings
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- BACKGROUND: Small intestinal bacterial overgrowth (SIBO) has been proposed to be common in irritable bowel syndrome (IBS), with altered small-bowel motility as a possible predisposing factor. AIM: To assess the prevalence of SIBO, by culture of small-bowel aspirate, and its correlation to symptoms and motility in IBS. METHODS: 162 patients with IBS who underwent small-bowel manometry and culture of jejunal aspirate were included. Cultures from 26 healthy subjects served as controls. Two definitions of altered flora were used: the standard definition of SIBO (>/=10(5) colonic bacteria/ml), and mildly increased counts of small-bowel bacteria (>/=95th centile in controls). RESULTS: SIBO (as per standard definition) was found in 4% of both patients and controls. Signs of enteric dysmotility were seen in 86% of patients with SIBO and in 39% of patients without SIBO (p = 0.02). Patients with SIBO had fewer phase III activities (activity fronts) than patients without SIBO (p = 0.08), but otherwise no differences in motility parameters were seen. Mildly increased bacterial counts (>/=5x10(3)/ml) were more common in patients with IBS than in controls (43% vs 12%; p = 0.002), but this was unrelated to small intestinal motility. No correlation between bacterial alterations and symptom pattern was observed. CONCLUSIONS: The data do not support an important role for SIBO according to commonly used clinical definitions, in IBS. However, mildly increased counts of small-bowel bacteria seem to be more common in IBS, and needs further investigation. Motility alterations could not reliably predict altered small-bowel bacterial flora.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- Adult
- Aged
- Anti-Bacterial Agents
- therapeutic use
- Bacteria
- growth & development
- isolation & purification
- Bacterial Infections
- complications
- drug therapy
- Breath Tests
- methods
- Constipation
- microbiology
- physiopathology
- Diarrhea
- microbiology
- physiopathology
- Female
- Gastrointestinal Motility
- Humans
- Intestine
- Small
- microbiology
- physiopathology
- Irritable Bowel Syndrome
- drug therapy
- microbiology
- physiopathology
- Jejunum
- microbiology
- Male
- Manometry
- methods
- Middle Aged
- Treatment Outcome
Publication and Content Type
- ref (subject category)
- art (subject category)
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