onr:"swepub:oai:gup.ub.gu.se/57790"
Search: onr:"swepub:oai:gup.ub.gu.se/57790" > Cell proliferation ...
- 1 of 1
- Previous record
- Next record
- To hitlist
Cell proliferation in the gastric epithelium of the ulcer rat.
-
- Helander, Herbert F, 1935 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för gastroforskning,Institute of Surgical Sciences, Department of Gastro Research
- Li, H (author)
- (creator_code:org_t)
- 2009-07-08
- 2005
- English.
- In: Scandinavian journal of gastroenterology. - : Informa UK Limited. - 0036-5521 .- 1502-7708. ; 40:12, s. 1386-93
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- OBJECTIVE: Cell division is brisk in the ulcer margin and many of the new cells will migrate over and cover the ulcer bed. The aim of this study was to determine how agents that promote or delay gastric ulcer healing influence cell proliferation in the gastric epithelium. MATERIAL AND METHODS: Acetic acid ulcers were produced in the rat gastric corpus; non-ulcer rats served as controls. All rats were given a continuous infusion of (3)H-thymidine. Some rats were also given gastrin or indomethacin, or infected with Helicobacter pylori. The rats were killed after 1, 2, 6 or 13 days, and the ulcer margin and undamaged corpus were excised for determination of labeling index (LI) by autoradiography. Antrum, duodenum and colon were also studied. Silver grain counting was carried out in some groups. RESULTS: LI in the ulcer margin grew exponentially, reaching 84% after 6 days; gastrin increased, and indomethacin decreased LI significantly. In 6-day ulcer rats that were given 3H-thymidine only during the first day LI was 5%, while in those given 3H-thymidine only during the last day LI was 27%. LI and silver grain counting results indicated that during the first 6 days of healing the epithelial cells in the ulcer margin divide twice. In the undamaged epithelium of the 1-day ulcer rats LI was
Keyword
- Acetic Acid
- Animals
- Anti-Inflammatory Agents
- Non-Steroidal
- pharmacology
- Cell Proliferation
- drug effects
- Epithelial Cells
- drug effects
- physiology
- Female
- Gastric Mucosa
- drug effects
- pathology
- physiopathology
- Gastrins
- physiology
- Helicobacter Infections
- complications
- Indomethacin
- pharmacology
- Rats
- Rats
- Sprague-Dawley
- Stomach Ulcer
- chemically induced
- pathology
- physiopathology
- Thymidine
- analogs & derivatives
- pharmacology
- Wound Healing
- drug effects
- physiology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Scandinavian journal of gastroenterology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Helander, Herber ...
- Li, H
- Articles in the publication
- Scandinavian jou ...
- By the university
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
