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Effects of antiretr...
Effects of antiretroviral treatment on blood-brain barrier integrity and intrathecal immunoglobulin production in neuroasymptomatic HIV-1-infected patients.
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- Abdulle, Sahra, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar,Institute of Internal Medicine, Dept of Infectious Diseases
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- Hagberg, Lars, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar,Institute of Internal Medicine, Dept of Infectious Diseases
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- Gisslén, Magnus, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar,Institute of Internal Medicine, Dept of Infectious Diseases
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(creator_code:org_t)
- Wiley, 2005
- 2005
- English.
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In: HIV medicine. - : Wiley. - 1464-2662 .- 1468-1293. ; 6:3, s. 164-9
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Abstract
Subject headings
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- OBJECTIVES: To study the effect of antiretroviral combination therapy on blood-brain barrier (BBB) integrity and intrathecal immunoglobulin G (IgG) production. METHODS: Lumbar punctures were performed on 38 neurologically asymptomatic, treatment-naive HIV-1-infected patients prior to and during treatment at intervals of approximately 4 months, 1 year and 2 years. Albumin ratio and IgG index were analysed as markers of BBB integrity and intrathecal IgG synthesis. RESULTS: HIV-1 RNA decreased to < 50 HIV-1 RNA copies/mL in the cerebrospinal fluid (CSF) of all patients and in the plasma of all but one patient. Only 5% of patients had elevated albumin ratio values at baseline, while 56% had an elevated IgG index. There was no significant reduction of the albumin ratio or the IgG index. After 2 years of treatment all patients had normal albumin ratio values, while 41% still had increased IgG index levels. CONCLUSIONS: Up to 2 years after the initiation of treatment, the favourable impact of antiretroviral combination treatment on CSF viral load was not accompanied by a similar reduction of intrathecal IgG production. BBB function, measured as the albumin ratio, was not significantly changed in this cohort of neurologically asymptomatic HIV-1-infected patients.
Keyword
- Adolescent
- Adult
- Anti-HIV Agents
- pharmacology
- therapeutic use
- Antiretroviral Therapy
- Highly Active
- Blood-Brain Barrier
- drug effects
- Brain
- drug effects
- immunology
- CD4 Lymphocyte Count
- Female
- Follow-Up Studies
- HIV Infections
- drug therapy
- immunology
- metabolism
- HIV-1
- genetics
- Humans
- Immunoglobulin G
- blood
- cerebrospinal fluid
- Immunoglobulins
- biosynthesis
- blood
- cerebrospinal fluid
- Male
- Middle Aged
- RNA
- Viral
- analysis
- Serum Albumin
- analysis
- Statistics
- Nonparametric
Publication and Content Type
- ref (subject category)
- art (subject category)
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