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Renal angioplasty c...
Renal angioplasty causes a rapid transient increase in inflammatory biomarkers, but reduced levels of interleukin-6 and endothelin-1 1 month after intervention.
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- Alhadad, Alaa (author)
- Lund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups
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- Guron, Gregor, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska University Hospital
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- Fortuna-Nowakowska, Ella (author)
- Sahlgrenska University Hospital
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- Saeed, Aso, 1971 (author)
- Sahlgrenska University Hospital
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- Mattiasson, Ingrid (author)
- Lund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups
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- Jensen, Gert, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska University Hospital
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- Gottsäter, Anders (author)
- Lund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups,Skåne University Hospital
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- Herlitz, Hans, 1946 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska University Hospital
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- Lindblad, Bengt (author)
- Lund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups
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(creator_code:org_t)
- 2007
- 2007
- English.
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In: Journal of hypertension. - 0263-6352 .- 1473-5598. ; 25:9, s. 1907-14
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Abstract
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- OBJECTIVE: To examine prospectively whether inflammatory biomarkers and endothelin (ET)-1 are increased in patients with renal artery stenosis (RAS), and to investigate how treatment with percutaneous transluminal renal angioplasty (PTRA) affects these variables during the first month after intervention. METHODS: One hundred patients with suspected RAS undergoing renal angiography were included. PTRA was performed if the trans-stenotic mean arterial pressure gradient was>or=10 mmHg. High-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNFalpha), neopterin, CD40 ligand (CD40L) and endothelin-1 (ET-1) were measured before, and 1 day and 1 month after PTRA (n=61) or diagnostic angiography only (n=39). RESULTS: At baseline there were no significant differences in inflammatory biomarkers or ET-1 levels between patients subsequently undergoing PTRA or angiography only. After angiography, IL-6 and hs-CRP had increased in both groups compared to baseline (P<0.001). At this time point hs-CRP (10.90+/-1.48 versus 6.37+/-1.61 mg/l; P<0.05) and IL-6 (13.70+/-0.94 versus 13.00+/-0.17 pg/ml; P<0.01) were higher in the PTRA group than in patients subjected to angiography only. One month after PTRA, systolic blood pressure and levels of IL-6 and ET-1 were lower than before intervention (P<0.05), whereas CD40L had increased compared to baseline (P<0.01). CONCLUSION: In patients with RAS, PTRA triggers rapid transient increases in hs-CRP and IL-6; however, 1 month after PTRA, both IL-6 and ET-1 had decreased compared to before intervention, indicating beneficial effects of PTRA on inflammation and the endothelin system.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Aged
- Angioplasty
- methods
- Biological Markers
- blood
- Blood Pressure
- Endothelin-1
- blood
- Female
- Humans
- Inflammation
- metabolism
- Interleukin-6
- blood
- Kidney
- blood supply
- physiopathology
- Male
- Middle Aged
- renovascular hypertension
- renal artery stenosis
- tumor necrosis
- factor-alpha
- percutaneous transluminal renal angioplasty
- neopterin
- interleukin-6
- inflammation
- endothelin-1
- cD40 ligand
- C-reactive protein
- CD40 ligand
- Neopterin
- Percutaneous transluminal renal angioplasty
- Renal artery stenosis
- Renovascular hypertension
- Tumor necrosis factor-α
Publication and Content Type
- ref (subject category)
- art (subject category)
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Alhadad, Alaa
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Guron, Gregor, 1 ...
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Fortuna-Nowakows ...
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Saeed, Aso, 1971
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Mattiasson, Ingr ...
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Jensen, Gert, 19 ...
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Gottsäter, Ander ...
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Herlitz, Hans, 1 ...
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Lindblad, Bengt
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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Journal of hyper ...
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University of Gothenburg
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Lund University