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Children born to HI...
Children born to HIV-1-infected women in Sweden in 1982-2003: trends in epidemiology and vertical transmission.
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- Navér, Lars (author)
- Karolinska Institutet
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Lindgren, Susanne (author)
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Belfrage, Erik (author)
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Gyllensten, Katarina (author)
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Lidman, Knut (author)
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- Gisslén, Magnus, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Ehrnst, Anneka (author)
- Karolinska Institutet
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Arneborn, Malin (author)
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- Bohlin, Ann-Britt (author)
- Karolinska Institutet
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2006
- 2006
- English.
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In: Journal of acquired immune deficiency syndromes (1999). - : Ovid Technologies (Wolters Kluwer Health). - 1525-4135. ; 42:4, s. 484-9
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Abstract
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- To describe the HIV-1 epidemic among childbearing women and their children in Sweden, a population-based analysis of data on all known mother-child pairs in Sweden with perinatal exposure to HIV-1 1982-2003 was conducted. The mother-to-child transmission (MTCT) rate in children prospectively followed from birth decreased from 24.7% in 1985-1993 to 5.7% in 1994-1998 and 0.6% in 1999-2003. The use of antiretroviral treatment of the mother during pregnancy and/or prophylactic antiretroviral intervention increased from 2.3% to 91.6% during the same period, and the elective cesarean delivery rate increased from 8.0% to 80.3%. No MTCT of HIV-1 occurred in Sweden after 1999.Fifty-one vertically HIV-1-infected children aged 2.7 to 17.6 years were living in Sweden by 31 December 2003, 71% being treated with antiretroviral agents. No HIV-1-related child death has been reported in Sweden after 1996. The conclusion is that MTCT of HIV-1 can be almost eliminated when appropriate resources are available. A national pregnancy screening program for HIV-1 running since 1987 with a high acceptance rate and the implementation of measures to prevent MTCT since 1994 have resulted in a significant decrease in the number of infected children. Inasmuch as knowledge of the infection status of the mother is crucial for reduction in MTCT of HIV-1, continued antenatal screening is important even in a low-prevalence country such as Sweden.
Keyword
- Adult
- Disease Transmission
- Vertical
- Female
- HIV Infections
- epidemiology
- transmission
- HIV-1
- Humans
- Infant
- Pregnancy
- Prospective Studies
- Sweden
- epidemiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Navér, Lars
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Lindgren, Susann ...
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Belfrage, Erik
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Gyllensten, Kata ...
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Lidman, Knut
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Gisslén, Magnus, ...
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show more...
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Ehrnst, Anneka
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Arneborn, Malin
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Bohlin, Ann-Brit ...
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Journal of acqui ...
- By the university
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University of Gothenburg
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Karolinska Institutet