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Variation in FTO co...
Variation in FTO contributes to childhood obesity and severe adult obesity.
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Dina, Christian (author)
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Meyre, David (author)
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Gallina, Sophie (author)
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Durand, Emmanuelle (author)
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Körner, Antje (author)
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- Jacobson, Peter, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Carlsson, Lena M S, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Kiess, Wieland (author)
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Vatin, Vincent (author)
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Lecoeur, Cecile (author)
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Delplanque, Jérome (author)
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Vaillant, Emmanuel (author)
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Pattou, François (author)
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Ruiz, Juan (author)
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Weill, Jacques (author)
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Levy-Marchal, Claire (author)
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Horber, Fritz (author)
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Potoczna, Natascha (author)
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Hercberg, Serge (author)
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Le Stunff, Catherine (author)
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Bougnères, Pierre (author)
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Kovacs, Peter (author)
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Marre, Michel (author)
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Balkau, Beverley (author)
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Cauchi, Stéphane (author)
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Chèvre, Jean-Claude (author)
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Froguel, Philippe (author)
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(creator_code:org_t)
- 2007-05-13
- 2007
- English.
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In: Nature genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 39:6, s. 724-6
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Abstract
Subject headings
Close
- We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and severe obesity in both adults and children of European ancestry with an experiment-wise P value of 1.67 x 10(-26) in 2,900 affected individuals and 5,100 controls. The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.
Keyword
- Adiposity
- Adult
- Age of Onset
- Body Composition
- Body Mass Index
- Case-Control Studies
- Child
- Chromosomes
- Human
- Pair 16
- genetics
- Cohort Studies
- Europe
- Female
- Genetic Predisposition to Disease
- Humans
- Introns
- genetics
- Male
- Middle Aged
- Obesity
- genetics
- Polymorphism
- Single Nucleotide
- genetics
- Variation (Genetics)
- genetics
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Dina, Christian
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Meyre, David
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Gallina, Sophie
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Durand, Emmanuel ...
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Körner, Antje
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Jacobson, Peter, ...
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show more...
-
Carlsson, Lena M ...
-
Kiess, Wieland
-
Vatin, Vincent
-
Lecoeur, Cecile
-
Delplanque, Jéro ...
-
Vaillant, Emmanu ...
-
Pattou, François
-
Ruiz, Juan
-
Weill, Jacques
-
Levy-Marchal, Cl ...
-
Horber, Fritz
-
Potoczna, Natasc ...
-
Hercberg, Serge
-
Le Stunff, Cathe ...
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Bougnères, Pierr ...
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Kovacs, Peter
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Marre, Michel
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Balkau, Beverley
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Cauchi, Stéphane
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Chèvre, Jean-Cla ...
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Froguel, Philipp ...
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show less...
- Articles in the publication
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Nature genetics
- By the university
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University of Gothenburg