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  • Dina, Christian (author)

Variation in FTO contributes to childhood obesity and severe adult obesity.

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • 2007-05-13
  • Springer Science and Business Media LLC,2007

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/58295
  • https://gup.ub.gu.se/publication/58295URI
  • https://doi.org/10.1038/ng2048DOI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and severe obesity in both adults and children of European ancestry with an experiment-wise P value of 1.67 x 10(-26) in 2,900 affected individuals and 5,100 controls. The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.

Subject headings and genre

  • Adiposity
  • Adult
  • Age of Onset
  • Body Composition
  • Body Mass Index
  • Case-Control Studies
  • Child
  • Chromosomes
  • Human
  • Pair 16
  • genetics
  • Cohort Studies
  • Europe
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Introns
  • genetics
  • Male
  • Middle Aged
  • Obesity
  • genetics
  • Polymorphism
  • Single Nucleotide
  • genetics
  • Variation (Genetics)
  • genetics

Added entries (persons, corporate bodies, meetings, titles ...)

  • Meyre, David (author)
  • Gallina, Sophie (author)
  • Durand, Emmanuelle (author)
  • Körner, Antje (author)
  • Jacobson, Peter,1962Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xjacop (author)
  • Carlsson, Lena M S,1957Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xcarle (author)
  • Kiess, Wieland (author)
  • Vatin, Vincent (author)
  • Lecoeur, Cecile (author)
  • Delplanque, Jérome (author)
  • Vaillant, Emmanuel (author)
  • Pattou, François (author)
  • Ruiz, Juan (author)
  • Weill, Jacques (author)
  • Levy-Marchal, Claire (author)
  • Horber, Fritz (author)
  • Potoczna, Natascha (author)
  • Hercberg, Serge (author)
  • Le Stunff, Catherine (author)
  • Bougnères, Pierre (author)
  • Kovacs, Peter (author)
  • Marre, Michel (author)
  • Balkau, Beverley (author)
  • Cauchi, Stéphane (author)
  • Chèvre, Jean-Claude (author)
  • Froguel, Philippe (author)
  • Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin (creator_code:org_t)

Related titles

  • In:Nature genetics: Springer Science and Business Media LLC39:6, s. 724-61061-40361546-1718

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