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Variation in FTO co...
Variation in FTO contributes to childhood obesity and severe adult obesity.
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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2007-05-13
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Springer Science and Business Media LLC,2007
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/58295
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https://gup.ub.gu.se/publication/58295URI
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https://doi.org/10.1038/ng2048DOI
Supplementary language notes
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and severe obesity in both adults and children of European ancestry with an experiment-wise P value of 1.67 x 10(-26) in 2,900 affected individuals and 5,100 controls. The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.
Subject headings and genre
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Adiposity
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Adult
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Age of Onset
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Body Composition
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Body Mass Index
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Case-Control Studies
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Child
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Chromosomes
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Human
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Pair 16
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genetics
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Cohort Studies
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Europe
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Female
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Genetic Predisposition to Disease
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Humans
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Introns
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genetics
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Male
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Middle Aged
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Obesity
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genetics
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Polymorphism
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Single Nucleotide
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genetics
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Variation (Genetics)
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genetics
Added entries (persons, corporate bodies, meetings, titles ...)
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Meyre, David
(author)
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Gallina, Sophie
(author)
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Durand, Emmanuelle
(author)
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Körner, Antje
(author)
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Jacobson, Peter,1962Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xjacop
(author)
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Carlsson, Lena M S,1957Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xcarle
(author)
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Kiess, Wieland
(author)
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Vatin, Vincent
(author)
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Lecoeur, Cecile
(author)
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Delplanque, Jérome
(author)
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Vaillant, Emmanuel
(author)
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Pattou, François
(author)
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Ruiz, Juan
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Weill, Jacques
(author)
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Levy-Marchal, Claire
(author)
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Horber, Fritz
(author)
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Potoczna, Natascha
(author)
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Hercberg, Serge
(author)
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Le Stunff, Catherine
(author)
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Bougnères, Pierre
(author)
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Kovacs, Peter
(author)
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Marre, Michel
(author)
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Balkau, Beverley
(author)
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Cauchi, Stéphane
(author)
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Chèvre, Jean-Claude
(author)
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Froguel, Philippe
(author)
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Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin
(creator_code:org_t)
Related titles
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In:Nature genetics: Springer Science and Business Media LLC39:6, s. 724-61061-40361546-1718
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Dina, Christian
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Meyre, David
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Gallina, Sophie
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Durand, Emmanuel ...
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Körner, Antje
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Jacobson, Peter, ...
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Carlsson, Lena M ...
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Kiess, Wieland
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Vatin, Vincent
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Lecoeur, Cecile
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Delplanque, Jéro ...
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Vaillant, Emmanu ...
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Pattou, François
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Ruiz, Juan
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Weill, Jacques
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Levy-Marchal, Cl ...
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Horber, Fritz
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Potoczna, Natasc ...
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Hercberg, Serge
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Le Stunff, Cathe ...
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Bougnères, Pierr ...
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Kovacs, Peter
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Marre, Michel
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Balkau, Beverley
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Cauchi, Stéphane
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Nature genetics
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University of Gothenburg