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Post-surgical use o...
Post-surgical use of radioiodine (131I) in patients with papillary and follicular thyroid cancer and the issue of remnant ablation: a consensus report.
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Pacini, Furio (author)
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Schlumberger, Martin (author)
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Harmer, Clive (author)
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- Berg, Gertrud, 1944 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för onkologi,Institute of Selected Clinical Sciences, Department of Oncology
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Cohen, Ohad (author)
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Duntas, Leonidas (author)
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Jamar, François (author)
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Jarzab, Barbara (author)
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Limbert, Eduard (author)
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Lind, Peter (author)
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Reiners, Cristoph (author)
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Sanchez Franco, Franco (author)
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Smit, Johannes (author)
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Wiersinga, Wilmar (author)
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(creator_code:org_t)
- Oxford University Press (OUP), 2005
- 2005
- English.
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In: European journal of endocrinology / European Federation of Endocrine Societies. - : Oxford University Press (OUP). - 0804-4643. ; 153:5, s. 651-9
- Related links:
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https://eje.bioscien...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- OBJECTIVE: To determine, based on published literature and expert clinical experience, current indications for the post-surgical administration of a large radioiodine activity in patients with differentiated thyroid cancer. DESIGN AND METHODS: A literature review was performed and was then analyzed and discussed by a panel of experts from 13 European countries. RESULTS: There is general agreement that patients with unifocal microcarcinomas = 1 cm in diameter and no node or distant metastases have a <2% recurrence rate after surgery alone, and that post-surgical radioiodine confers recurrence and cause-specific survival benefits in patients, strongly suspected of having persistent disease or known to have tumor in the neck or distant sites. In other patients, there is limited evidence that after complete thyroidectomy and adequate lymph node dissection performed by an expert surgeon, post-surgical radioiodine provides clear benefit. When there is any uncertainty about the completeness of surgery, evidence suggests that radioiodine can reduce recurrences and possibly mortality. CONCLUSION: This survey confirms that post-surgical radioiodine should be used selectively. The modality is definitely indicated in patients with distant metastases, incomplete tumor resection, or complete tumor resection but high risk of recurrence and mortality. Probable indications include patients with tumors >1 cm and with suboptimal surgery (less than total thyroidectomy or no lymph node dissection), with age <16 years, or with unfavorable histology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Carcinoma
- Papillary
- Follicular
- radiotherapy
- surgery
- Consensus
- Humans
- Iodine Radioisotopes
- therapeutic use
- Neoplasm
- Residual
- surgery
- Postoperative Care
- Radiotherapy
- Adjuvant
- Thyroid Neoplasms
- radiotherapy
- surgery
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Pacini, Furio
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Schlumberger, Ma ...
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Harmer, Clive
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Berg, Gertrud, 1 ...
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Cohen, Ohad
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Duntas, Leonidas
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show more...
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Jamar, François
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Jarzab, Barbara
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Limbert, Eduard
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Lind, Peter
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Reiners, Cristop ...
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Sanchez Franco, ...
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Smit, Johannes
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Wiersinga, Wilma ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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European journal ...
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European Journal ...
- By the university
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University of Gothenburg