Nonsearch paradigm for large-scale parameter-identification problems in dynamical systems related to oncogenic hyperplasia

• In many engineering and biomedical problems there is a need to identify parameters of the systems from experimental data. A typical example is the biochemical-kinetics systems describing oncogenic hyperplasia where the dynamical model is nonlinear and the number of the parameters to be identified can reach a few hundreds. Solving these large-scale identification problems by the local- or global-search methods can not be practical because of the complexity and prohibitive computing time. These difficulties can be overcome by application of the non-search techniques which are much less computation- demanding. The present work proposes key components of the corresponding mathematical formulation of the nonsearch paradigm. This new framework for the nonlinear large-scale parameter identification specifies and further develops the ideas of the well-known approach of A. Krasovskii. The issues are illustrated with a concise analytical example. The new results and a few directions for future research are summarized in a dedicated section.

Subject headings

NATURVETENSKAP  -- Matematik -- Matematisk analys (hsv//swe)

NATURAL SCIENCES  -- Mathematics -- Mathematical Analysis (hsv//eng)

NATURVETENSKAP  -- Fysik -- Annan fysik (hsv//swe)

NATURAL SCIENCES  -- Physical Sciences -- Other Physics Topics (hsv//eng)

NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)

NATURVETENSKAP  -- Matematik -- Beräkningsmatematik (hsv//swe)

NATURAL SCIENCES  -- Mathematics -- Computational Mathematics (hsv//eng)

TEKNIK OCH TEKNOLOGIER  -- Elektroteknik och elektronik (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Electrical Engineering, Electronic Engineering, Information Engineering (hsv//eng)

Keyword

nonlinear dynamic system

non-search parameter identification

Krasovskii method

biochemical kinetics

Biochemical kinetics

Publication and Content Type

ref (subject category)

kon (subject category)