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Endocrine, liver-de...
Endocrine, liver-derived IGF-I is of importance for spatial learning and memory in old mice.
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- Svensson, Johan, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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- Diez, M (author)
- Karolinska Institutet
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- Engel, Jörgen, 1942 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology
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- Wass, Caroline, 1976 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology
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- Tivesten, Åsa, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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- Jansson, John-Olov, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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- Isaksson, Olle, 1943 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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- Archer, Trevor, 1949 (author)
- Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology
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- Hökfelt, Tomas (author)
- Karolinska Institutet
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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(creator_code:org_t)
- Bioscientifica, 2006
- 2006
- English.
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In: The Journal of endocrinology. - : Bioscientifica. - 0022-0795 .- 1479-6805. ; 189:3, s. 617-27
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Abstract
Subject headings
Close
- IGF-I is a neuroprotective hormone, and neurodegenerative disorders, including Alzheimer's disease, have been associated with decreased serum IGF-I concentration. In this study, IGF-I production was inactivated in the liver of adult mice (LI-IGF-I(-/-)), resulting in an approximately 80-85% reduction of circulating IGF-I concentrations. In young (6-month-old) mice there was no difference between the LI-IGF-I(-/-) and the control mice in spatial learning and memory as measured using the Morris water maze test. In old (aged 15 and 18 months) LI-IGF-I(-/-) mice, however, the acquisition of the spatial task was slower than in the controls. Furthermore, impaired spatial working as well as reference memory was observed in the old LI-IGF(-/-) mice. Histochemical analyses revealed an increase in dynorphin and enkephalin immunoreactivities but decreased mRNA levels in the hippocampus of old LI-IGF-I(-/-) mice. These mice also displayed astrocytosis and increased metabotropic glutamate receptor 7a-immunoreactivity. These neurochemical disturbances suggest synaptic dysfunction and early neurodegeneration in old LI-IGF-I(-/-) mice. The decline in serum IGF-I with increasing age may therefore be important for the age-related decline in memory function.
Keyword
- Aging
- physiology
- Alzheimer Disease
- metabolism
- Animals
- Female
- Immunohistochemistry
- methods
- In Situ Hybridization
- Insulin-Like Growth Factor I
- metabolism
- Liver
- metabolism
- Maze Learning
- Memory
- Mice
- Mice
- Knockout
- Models
- Animal
- Poly I-C
- pharmacology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Svensson, Johan, ...
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Diez, M
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Engel, Jörgen, 1 ...
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Wass, Caroline, ...
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Tivesten, Åsa, 1 ...
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Jansson, John-Ol ...
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show more...
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Isaksson, Olle, ...
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Archer, Trevor, ...
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Hökfelt, Tomas
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Ohlsson, Claes, ...
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- Articles in the publication
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The Journal of e ...
- By the university
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University of Gothenburg
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Karolinska Institutet