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Autoantibodies agai...
Autoantibodies against M2-muscarinic acetylcholine receptors: new upstream targets in atrial fibrillation in patients with dilated cardiomyopathy.
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Baba, Akiyasu (author)
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Yoshikawa, Tsutomu (author)
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Fukuda, Yukiko (author)
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Sugiyama, Takashi (author)
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Shimada, Megumi (author)
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Akaishi, Makoto (author)
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Tsuchimoto, Kanji (author)
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Ogawa, Satoshi (author)
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- Fu, Michael, 1963 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för invärtesmedicin,Wallenberg Laboratory,Institute of Internal Medicine
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(creator_code:org_t)
- Oxford University Press (OUP), 2004
- 2004
- English.
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In: European heart journal. - : Oxford University Press (OUP). - 0195-668X. ; 25:13, s. 1108-15
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- AIM: To characterise the clinical significance of M2-muscarinic acetylcholine receptor autoantibodies (M2-AAB) in patients with dilated cardiomyopathy (DCM). METHODS AND RESULTS: Sera from 104 patients with DCM, age-matched with 104 patients with idiopathic atrial fibrillation (Af) and 104 healthy control subjects, were screened for M2-AAB by enzyme-linked immunosorbent assay (ELISA). IgG purified by Protein-A column was also used as a primary antibody in ELISA. In DCM, M2-AAB were detected in 40% of patients using whole sera and in 36% of patients using purified IgG. M2-AAB were also found in several patients with idiopathic Af (23%, 23%), and these frequencies were significantly higher than those in healthy subjects (8%, 8%). Af was more common in AAB-positive than in AAB-negative patients with DCM. Multivariable analysis confirmed that M2-AAB were independent predictors of the presence of Af in such patients. We determined electrophysiological changes by adding patient purified M2-AAB to chick embryos. Purified IgG from both Af and DCM patients exhibited negative chronotropic effects and induced supraventricular arrhythmias. CONCLUSION: M2-AAB may play a role in mediating the development of Af in patients with DCM.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Atrial Fibrillation
- immunology
- Autoantibodies
- analysis
- Cardiomyopathy
- Dilated
- complications
- immunology
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Immunoglobulin G
- analysis
- Male
- Middle Aged
- Receptor
- Muscarinic M2
- immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Baba, Akiyasu
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Yoshikawa, Tsuto ...
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Fukuda, Yukiko
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Sugiyama, Takash ...
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Shimada, Megumi
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Akaishi, Makoto
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show more...
-
Tsuchimoto, Kanj ...
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Ogawa, Satoshi
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Fu, Michael, 196 ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
- Articles in the publication
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European heart j ...
- By the university
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University of Gothenburg