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Budesonide/Formoter...
Budesonide/Formoterol combination therapy as both maintenance and reliever medication in asthma
- Article/chapterEnglish2005
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LIBRIS-ID:oai:gup.ub.gu.se/60049
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https://gup.ub.gu.se/publication/60049URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Asthma control is improved by combining inhaled corticosteroids with long-acting beta(2)-agonists. However, fluctuating asthma control still occurs. We hypothesized that in patients receiving low maintenance dose budesonide/formoterol (bud/form), replacing short-acting beta(2)-agonist (SABA) reliever with as-needed bud/form would provide rapid symptom relief and simultaneous adjustment in antiinflammatory therapy, thereby reducing exacerbations. In this double-blind, randomized, parallel-group study, 2,760 patients with asthma aged 4-80 years (FEV(1) 60-100% predicted) received either terbutaline 0.4 mg as SABA with bud/form 80/4.5 mug twice a day (bud/form + SABA) or bud 320 mug twice a day (bud + SABA) or bud/form 80/4.5 mug twice a day with 80/4.5 mug as-needed (bud/form maintenance + relief). Children used a once-nocte maintenance dose. Bud/form maintenance + relief prolonged time to first severe exacerbation (p < 0.001; primary endpoint), resulting in a 45-47% lower exacerbation risk versus bud/form + SABA (hazard ratio, 0.55; 95% confidence interval, 0.44, 0.67) or bud + SABA (hazard ratio, 0.53; 95% confidence interval 0.43, 0.65). Bud/form maintenance + relief also prolonged the time to the first, second, and third exacerbation requiring medical intervention (p < 0.001), reduced severe exacerbation rate, and improved symptoms, awakenings, and lung function compared with both fixed dosing regimens.
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Bisgaard, H.
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Godard, P. P.
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Pistolesi, M.
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Palmqvist, Mona,1957Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi,Institute of Internal Medicine, Dept of Respiratory Medicine/Allergology(Swepub:gu)xpamon
(author)
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Zhu, Y.
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Ekström, T.
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Bateman, E. D.
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Göteborgs universitetInstitutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi
(creator_code:org_t)
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In:Am J Respir Crit Care Med171:2, s. 129-36
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