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Receptor recruitmen...
Receptor recruitment: a mechanism for interactions between G protein-coupled receptors.
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Holtbäck, U (author)
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- Brismar, H (author)
- Karolinska Institutet
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DiBona, G F (author)
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- Fu, Michael, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Wallenberglaboratoriet,Institute of Internal Medicine,Wallenberg Laboratory
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Greengard, P (author)
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- Aperia, A (author)
- Karolinska Institutet
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(creator_code:org_t)
- Proceedings of the National Academy of Sciences, 1999
- 1999
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 96:13, s. 7271-5
- Related links:
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http://www.pnas.org/...
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https://doi.org/10.1...
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Abstract
Subject headings
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- There is a great deal of evidence for synergistic interactions between G protein-coupled signal transduction pathways in various tissues. As two specific examples, the potent effects of the biogenic amines norepinephrine and dopamine on sodium transporters and natriuresis can be modulated by neuropeptide Y and atrial natriuretic peptide, respectively. Here, we report, using a renal epithelial cell line, that both types of modulation involve recruitment of receptors from the interior of the cell to the plasma membrane. The results indicate that recruitment of G protein-coupled receptors may be a ubiquitous mechanism for receptor sensitization and may play a role in the modulation of signal transduction comparable to that of the well established phenomenon of receptor endocytosis and desensitization.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Adrenergic alpha-Agonists
- pharmacology
- Animals
- Atrial Natriuretic Factor
- pharmacology
- Cells
- Cultured
- Dopamine
- pharmacology
- Drug Interactions
- GTP-Binding Proteins
- metabolism
- Kidney
- metabolism
- Na(+)-K(+)-Exchanging ATPase
- metabolism
- Neuropeptide Y
- pharmacology
- Norepinephrine
- pharmacology
- Rats
- Receptors
- Cell Surface
- metabolism
- Signal Transduction
- drug effects
Publication and Content Type
- ref (subject category)
- art (subject category)
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