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- Liu, H R (author)
Screening of serum autoantibodies to cardiac beta1-adrenoceptors and M2-muscarinic acetylcholine receptors in 408 healthy subjects of varying ages.
- Article/chapterEnglish1999
Publisher, publication year, extent ...
- 1999
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- LIBRIS-ID:oai:gup.ub.gu.se/60473
- https://gup.ub.gu.se/publication/60473URI
Supplementary language notes
- Language:English
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Notes
- Autoantibodies to cardiac beta1-adrenoceptors and M2-muscarinic receptors have mainly been found in the sera of patients with idiopathic dilated cardiomyopathy (DCM). In order to elucidate the pathological significance of these autoantibodies in DCM, it is necessary to understand their characteristic distribution in a healthy population of different genders and ages. The peptides corresponding to the sequences of the second extracellular loops of the human beta1-adrenoceptor and M2-muscarinic receptors were therefore used as antigens to screen the sera of 408 healthy subjects of different ages (ranging from 0.5 to 85 years). Of 408 sera, 41 (10.0%) and 46 (11.3%) recognized the beta1-adrenoceptor and M2-muscarinic receptor peptides respectively. Of the positive sera for beta1-adrenoceptors and M2-muscarinic receptors, up to 63.4% and 56.5% had both anti-beta1-adrenoceptor and anti-M2-muscarinic receptor autoantibodies respectively. The antibody titres of the positive sera of healthy subjects were all of a low level, with a geometric mean titre of 1:42+/-1.9 for anti-beta1-adrenoceptor antibodies and 1:51+/-1.7 for anti-M2-muscarinic receptor antibodies. The frequency of occurrence of autoantibodies to both receptors in the sera of healthy subjects increased significantly with age. In conclusion, the autoantibodies to beta1-adrenoceptors and M2-muscarinic receptors in the sera of healthy subjects are characterized by a low frequency of occurrence and low titre, with the frequency of occurrence increasing with age.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Mikrobiologi inom det medicinska området hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Microbiology in the medical area hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
- Adolescent
- Adult
- Age Factors
- Aged
- Autoantibodies
- blood
- Cardiomyopathy
- Dilated
- etiology
- immunology
- Child
- Child
- Preschool
- Female
- Humans
- Infant
- Male
- Middle Aged
- Myocardium
- immunology
- Receptor
- Muscarinic M2
- Receptors
- Adrenergic
- beta-1
- immunology
- Receptors
- Muscarinic
- immunology
- Sex Factors
Added entries (persons, corporate bodies, meetings, titles ...)
- Zhao, R R (author)
- Zhi, J M (author)
- Wu, B W (author)
- Fu, Michael,1963Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Wallenberglaboratoriet,Institute of Internal Medicine,Wallenberg Laboratory(Swepub:gu)xfumiw (author)
- Göteborgs universitetInstitutionen för invärtesmedicin (creator_code:org_t)
Related titles
- In:Autoimmunity29:1, s. 43-510891-6934
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