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- Zhou, Dapeng (author)
Lysosomal glycosphingolipid recognition by NKT cells.
- Article/chapterEnglish2004
Publisher, publication year, extent ...
- American Association for the Advancement of Science (AAAS),2004
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/60484
- https://gup.ub.gu.se/publication/60484URI
- https://doi.org/10.1126/science.1103440DOI
Supplementary language notes
- Language:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- NKT cells represent a distinct lineage of T cells that coexpress a conserved alphabeta T cell receptor (TCR) and natural killer (NK) receptors. Although the TCR of NKT cells is characteristically autoreactive to CD1d, a lipid-presenting molecule, endogenous ligands for these cells have not been identified. We show that a lysosomal glycosphingolipid of previously unknown function, isoglobotrihexosylceramide (iGb3), is recognized both by mouse and human NKT cells. Impaired generation of lysosomal iGb3 in mice lacking beta-hexosaminidase b results in severe NKT cell deficiency, suggesting that this lipid also mediates development of NKT cells in the mouse. We suggest that expression of iGb3 in peripheral tissues may be involved in controlling NKT cell responses to infections and malignancy and in autoimmunity.
Subject headings and genre
- Animals
- Antigen Presentation
- Antigens
- CD1
- immunology
- metabolism
- Autoimmunity
- Cell Line
- Cell Line
- Tumor
- Cells
- Cultured
- Dendritic Cells
- immunology
- Galactosyltransferases
- genetics
- metabolism
- Globosides
- chemistry
- immunology
- metabolism
- Humans
- Hybridomas
- Infection
- immunology
- Killer Cells
- Natural
- immunology
- Ligands
- Lymphocyte Activation
- Lymphocyte Count
- Lysosomes
- metabolism
- Mice
- Mice
- Inbred C57BL
- Neoplasms
- immunology
- Plant Lectins
- immunology
- Rats
- Receptors
- Antigen
- T-Cell
- alpha-beta
- immunology
- Saposins
- metabolism
- T-Lymphocyte Subsets
- immunology
- beta-N-Acetylhexosaminidase
- genetics
- metabolism
Added entries (persons, corporate bodies, meetings, titles ...)
- Mattner, Jochen (author)
- Cantu, Carlos (author)
- Schrantz, Nicolas (author)
- Yin, Ning (author)
- Gao, Ying (author)
- Sagiv, Yuval (author)
- Hudspeth, Kelly (author)
- Wu, Yun-Ping (author)
- Yamashita, Tadashi (author)
- Teneberg, Susann,1955Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry(Swepub:gu)xtensu (author)
- Wang, Dacheng (author)
- Proia, Richard L (author)
- Levery, Steven B (author)
- Savage, Paul B (author)
- Teyton, Luc (author)
- Bendelac, Albert (author)
- Göteborgs universitetInstitutionen för medicinsk och fysiologisk kemi (creator_code:org_t)
Related titles
- In:Science (New York, N.Y.): American Association for the Advancement of Science (AAAS)306:5702, s. 1786-91095-92030036-8075
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- Levery, Steven B
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