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Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM.
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- Carvalho, Eugénia, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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- Jansson, Per-Anders, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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- Axelsen, Mette, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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- Huang, X (author)
- Groop, L (author)
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- (creator_code:org_t)
- 1999
- 1999
- English.
- In: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. - 0892-6638 .- 1530-6860. ; 13:15, s. 2173-8
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- We examined the gene and protein expression of IRS 1 (insulin receptor substrate 1) in adipocytes from two groups of healthy individuals with an increased propensity for non-insulin-dependent diabetes mellitus (NIDDM): those with two first-degree relatives with diabetes and another group with massive obesity. A low expression of IRS 1 (
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Adult
- Biological Markers
- Diabetes Mellitus
- Type 2
- genetics
- metabolism
- Female
- Humans
- Insulin
- metabolism
- Insulin Resistance
- genetics
- Male
- Middle Aged
- Obesity
- genetics
- metabolism
- Phosphoproteins
- biosynthesis
- genetics
- Polymorphism
- Genetic
- Sequence Analysis
- DNA
- Triglycerides
- metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Sjöström, Lars
- Smith, Ulf, 1943
- Eriksson, Jan W
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