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Complement activation by both classical and alternative pathways is critical for the effector phase of arthritis.
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- Hietala, Max Albert, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry,Göteborg University, Göteborg, Sweden
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- Nandakumar, Kutty Selva, 1965- (author)
- Lund University, Lund, Sweden
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- Persson, Linda, 1971 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry,Göteborg University, Göteborg, Sweden
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- (creator_code:org_t)
- Wiley, 2004
- 2004
- English.
- In: European journal of immunology. - : Wiley. - 0014-2980 .- 1521-4141. ; 34:4, s. 1208-16
- Journal article (peer-reviewed)
Abstract
Subject headings
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- To analyze the role of the classical and alternative pathways of complement activation in the effector phase of arthritis, we have induced arthritis in C3- and factor B (FB)-deficient (C3(-/-) and FB(-/-)) DBA/1J mice using well-defined monoclonal IgG2b and IgG2a antibodies to type II collagen. In control DBA/1J mice, severe swelling of the joints, destruction of cartilage and erosion of bone developed very rapidly with a 100% incidence and a peak on days 7-10. Although 75% of C3(-/-) mice developed arthritis, the clinical severity was very mild and the onset was delayed. Severity of arthritis in FB(-/-) mice ranked intermediate in comparison with C3(-/-) and control mice with an incidence of 100%. Immunohistochemical analysis of the inflamed joints demonstrated substantial reduction in macrophage and neutrophilic leukocyte infiltration in both C3(-/-) and FB(-/-) mice, thereby confirming the clinical findings. We conclude that both the classical and the alternative pathways of complement activation are involved in the effector phase of arthritis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Animals
- Arthritis
- Experimental
- immunology
- pathology
- Complement Activation
- immunology
- Complement C3
- deficiency
- Complement Factor B
- deficiency
- Complement Pathway
- Alternative
- Complement Pathway
- Classical
- Enzyme-Linked Immunosorbent Assay
- Immunohistochemistry
- Inflammation
- immunology
- pathology
- Joints
- pathology
- Male
- Mice
- Mice
- Knockout
- Monocytes
- immunology
- pathology
- Neutrophils
- immunology
- pathology
- rodent
- complement
- rheumatoid arthritis
- transgenic
- knockout
- Animals
Publication and Content Type
- ref (subject category)
- art (subject category)
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