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Metabolic profile a...
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Falhammar, HenrikKarolinska Institutet
(author)
Metabolic profile and body composition in adult women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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The Endocrine Society,2007
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/61313
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https://gup.ub.gu.se/publication/61313URI
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https://doi.org/10.1210/jc.2006-1350DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1940577URI
Supplementary language notes
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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CONTEXT: The chronic, often supraphysiological glucocorticoid doses used in congenital adrenal hyperplasia (CAH) might increase morbidity in cardiovascular disease and diabetes. OBJECTIVE: Our aim was to assess risk factors for cardiovascular disease and diabetes in CAH women. SUBJECTS, METHODS, AND DESIGN: We compared 61 women, 18-63 yr, with CAH due to 21-hydroxylase deficiency with 61 age- and sex- matched controls. Twenty-seven were younger than 30 yr, and 34 were 30 yr or older. Anthropometry, fat and lean mass measured by dual-energy x-ray absorptiometry, serum lipids, insulin, and adrenocortical steroids were studied. MAIN OUTCOME MEASURE: Body composition and cardiovascular risk factors were the main outcome measures. RESULTS: Younger patients and controls had similar waist to hip ratio, lean and fat mass, and insulin. Older patients had higher waist to hip ratio, lean mass, and insulin than controls. Fat mass was similar to controls but higher than in younger patients. Lipid profiles were slightly more favorable in older patients than controls. Gestational diabetes was more common in patients (21% of pregnancies vs. 0, P < 0.026). Few older patients had hypertension, cardiovascular disease, or diabetes. Despite moderate glucocorticoid doses, most patients had suppressed androgens. CONCLUSIONS: No clear evidence of unfavorable cardiovascular risk factors were found. Increased fat mass and higher insulin levels were, however, found in patients older than 30 yr. High frequency of gestational diabetes is a risk marker for future diabetes. Lifelong follow-up, lifestyle modifications, and attempts to adjust and reduce the glucocorticoid doses seem important.
Subject headings and genre
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Adolescent
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Adrenal Hyperplasia
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Congenital
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complications
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metabolism
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Adult
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Blood Pressure
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Body Composition
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Body Mass Index
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Body Weight
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Cardiovascular Diseases
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etiology
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Dehydroepiandrosterone Sulfate
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blood
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Diabetes Mellitus
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etiology
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Female
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Humans
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Middle Aged
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Steroid 21-Hydroxylase
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analysis
Added entries (persons, corporate bodies, meetings, titles ...)
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Filipsson, Helena,1966Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xfilih
(author)
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Holmdahl, Gundela,1956Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xhogun
(author)
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Janson, Per-Olof,1940Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xjperm
(author)
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Nordenskjöld, AgnetaKarolinska Institutet
(author)
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Hagenfeldt, KerstinKarolinska Institutet
(author)
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Thorén, MarjaKarolinska Institutet
(author)
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Karolinska InstitutetInstitutionen för medicin, avdelningen för invärtesmedicin
(creator_code:org_t)
Related titles
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In:The Journal of clinical endocrinology and metabolism: The Endocrine Society92:1, s. 110-60021-972X1945-7197
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