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Inventory and analysis of the protein subunits of the ribonucleases P and MRP provides further evidence of homology between the yeast and human enzymes.
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- Alm Rosenblad, Magnus, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology
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- Davila Lopez, Marcela (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- Piccinelli, Paul, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- (creator_code:org_t)
- 2006-09-22
- 2006
- English.
- In: Nucleic acids research. - : Oxford University Press (OUP). - 1362-4962 .- 0305-1048. ; 34:18, s. 5145-56
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The RNases P and MRP are involved in tRNA and rRNA processing, respectively. Both enzymes in eukaryotes are composed of an RNA molecule and 9-12 protein subunits. Most of the protein subunits are shared between RNases P and MRP. We have here performed a computational analysis of the protein subunits in a broad range of eukaryotic organisms using profile-based searches and phylogenetic methods. A number of novel homologues were identified, giving rise to a more complete inventory of RNase P/MRP proteins. We present evidence of a relationship between fungal Pop8 and the protein subunit families Rpp14/Pop5 as well as between fungal Pop6 and metazoan Rpp25. These relationships further emphasize a structural and functional similarity between the yeast and human P/MRP complexes. We have also identified novel P and MRP RNAs and analysis of all available sequences revealed a K-turn motif in a large number of these RNAs. We suggest that this motif is a binding site for the Pop3/Rpp38 proteins and we discuss other structural features of the RNA subunit and possible relationships to the protein subunit repertoire.
Keyword
- Amino Acid Sequence
- Endoribonucleases
- chemistry
- classification
- genetics
- Fungal Proteins
- chemistry
- classification
- genetics
- Genomics
- Humans
- Molecular Sequence Data
- Phylogeny
- Protein Subunits
- chemistry
- classification
- genetics
- Ribonuclease P
- chemistry
- classification
- genetics
- Saccharomyces cerevisiae Proteins
- chemistry
- classification
- genetics
- Sequence Alignment
- Sequence Analysis
- RNA
- Sequence Homology
- Amino Acid
- Yeasts
- enzymology
Publication and Content Type
- ref (subject category)
- art (subject category)
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