Role of platelet-derived growth factor in mesangium development and vasculopathies: lessons from platelet-derived growth factor and platelet-derived growth factor receptor mutations in mice.

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Betsholtz, Christer,1959Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry (author)

Role of platelet-derived growth factor in mesangium development and vasculopathies: lessons from platelet-derived growth factor and platelet-derived growth factor receptor mutations in mice.

Article/chapterEnglish2004

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2004

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LIBRIS-ID:oai:gup.ub.gu.se/61628
https://gup.ub.gu.se/publication/61628URI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

PURPOSE OF REVIEW: The phenotypic consequences of null mutations in the platelet-derived growth factor-B and the platelet-derived growth factor beta-receptor genes in mice have demonstrated that these proteins play pivotal roles in the development of the vascular smooth muscle cell lineage, including pericytes and mesangial cells. RECENT FINDINGS: The lethality of these mutants has precluded analysis of the physiological and pathophysiological consequences of platelet-derived growth factor-B and platelet-derived growth factor beta-receptor deficiency in adults. This review summarizes and discusses recent data from certain tissue-specific and subtle mutations in the platelet-derived growth factor-B and platelet-derived growth factor beta-receptor genes that are compatible with postnatal viability in spite of severe developmental deficits in pericyte and mesangial cell recruitment. In the postnatal period, the animals studied developed a characteristic set of pathological changes to small blood vessels of the retina and the kidney glomerulus, which sheds light on the importance of pericytes and mesangial cells for vascular integrity and function after birth. SUMMARY: These microvascular abnormalities and their consequences bear a resemblance to diabetic microangiopathy and nephropathy. The platelet-derived growth factor-B and platelet-derived growth factor beta-receptor mutant mouse models, therefore, might serve as valuable tools in the dissection of some of the pathogenic events in diabetic microangiopathy.

Subject headings and genre

Animals
Glomerular Mesangium
growth & development
physiology
Glomerulosclerosis
Focal Segmental
physiopathology
Kidney Diseases
pathology
Mice
Mice
Knockout
Paracrine Communication
Pericytes
physiology
Platelet-Derived Growth Factor
genetics
physiology
Receptors
Platelet-Derived Growth Factor
genetics
physiology
Retinal Vasculitis
genetics
pathology
Vascular Diseases
etiology
pathology

Added entries (persons, corporate bodies, meetings, titles ...)

Lindblom, Per,1974Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry (author)
Bjarnegård, Mattias,1970Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry(Swepub:gu)xbjama (author)
Enge, Maria,1970Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry(Swepub:gu)xenmar (author)
Gerhardt, Holger,1969Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry (author)
Lindahl, Per,1967Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Wallenberglaboratoriet,Institute of Medical Biochemistry,Wallenberg Laboratory(Swepub:gu)xlindp (author)
Göteborgs universitetInstitutionen för medicinsk och fysiologisk kemi (creator_code:org_t)

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In:Current opinion in nephrology and hypertension13:1, s. 45-521062-4821

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