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Endothelial PDGF-B ...
Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall.
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- Lindblom, Per, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry
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- Gerhardt, Holger, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry
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Liebner, Stefan (author)
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- Abramsson, Alexandra, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry
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- Enge, Maria, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry
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Hellström, Mats (author)
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- Bäckström, Gudrun (author)
- Ludwiginstitutet för Cancerforskning
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- Fredriksson, Simon (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Landegren, Ulf (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Nyström, Henrik, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology
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- Bergström, Göran, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology
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Dejana, Elisabetta (author)
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- Östman, Arne (author)
- Ludwiginstitutet för Cancerforskning
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- Lindahl, Per, 1967 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicinsk och fysiologisk kemi,Wallenberg Laboratory,Institute of Medical Biochemistry
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- Betsholtz, Christer, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry
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(creator_code:org_t)
- 2003-08-01
- 2003
- English.
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In: Genes & development. - : Cold Spring Harbor Laboratory. - 0890-9369 .- 1549-5477. ; 17:15, s. 1835-40
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Abstract
Subject headings
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- Several platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) family members display C-terminal protein motifs that confer retention of the secreted factors within the pericellular space. To address the role of PDGF-B retention in vivo, we deleted the retention motif by gene targeting in mice. This resulted in defective investment of pericytes in the microvessel wall and delayed formation of the renal glomerulus mesangium. Long-term effects of lack of PDGF-B retention included severe retinal deterioration, glomerulosclerosis, and proteinuria. We conclude that retention of PDGF-B in microvessels is essential for proper recruitment and organization of pericytes and for renal and retinal function in adult mice.
Keyword
- Alleles
- Amino Acid Motifs
- Amino Acid Sequence
- Animals
- Cell Movement
- Endothelial Growth Factors
- metabolism
- Endothelium
- Vascular
- metabolism
- Glomerulosclerosis
- Focal Segmental
- genetics
- Intercellular Signaling Peptides and Proteins
- metabolism
- Kidney
- physiology
- Lymphokines
- metabolism
- Mice
- Microcirculation
- metabolism
- Microscopy
- Fluorescence
- Models
- Genetic
- Molecular Sequence Data
- Mutation
- Pericytes
- metabolism
- Phenotype
- Platelet-Derived Growth Factor
- metabolism
- Protein Structure
- Tertiary
- Proteinuria
- genetics
- Proto-Oncogene Proteins c-sis
- genetics
- metabolism
- Retina
- metabolism
- physiology
- Retinal Degeneration
- genetics
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
- Alleles
Publication and Content Type
- ref (subject category)
- art (subject category)
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Lindblom, Per, 1 ...
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Gerhardt, Holger ...
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Liebner, Stefan
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Abramsson, Alexa ...
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Enge, Maria, 197 ...
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Hellström, Mats
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Bäckström, Gudru ...
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Fredriksson, Sim ...
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Landegren, Ulf
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Nyström, Henrik, ...
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Bergström, Göran ...
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Dejana, Elisabet ...
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Östman, Arne
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Lindahl, Per, 19 ...
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Betsholtz, Chris ...
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- Articles in the publication
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Genes & developm ...
- By the university
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University of Gothenburg
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Uppsala University