Search: onr:"swepub:oai:gup.ub.gu.se/61681" >
Meta-analysis of ge...
Meta-analysis of genome-wide studies of psoriasis susceptibility reveals linkage to chromosomes 6p21 and 4q28-q31 in Caucasian and Chinese Hans population.
-
Sagoo, Gurdeep S (author)
-
Tazi-Ahnini, Rachid (author)
-
Barker, Jonathan W N (author)
-
show more...
-
Elder, James T (author)
-
Nair, Rajan P (author)
-
- Samuelsson, Lena, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics
-
Traupe, Heiko (author)
-
Trembath, Richard C (author)
-
Robinson, Darren A (author)
-
Iles, Mark M (author)
-
show less...
-
(creator_code:org_t)
- 2004
- 2004
- English.
-
In: The Journal of investigative dermatology. - 0022-202X. ; 122:6, s. 1401-5
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Ten genome-wide scans have been conducted over the past few years in the search for psoriasis susceptibility genes, but only one potential susceptibility region has been consistently replicated. A meta-analysis using the genome-search meta-analysis method was undertaken combining the results of six of these psoriasis genome-wide studies. The results of this analysis revealed linkage to the major histocompatibility complex on chromosome 6p21 that includes the PSORS1 locus. In addition, linkage was also recorded to a region on chromosome 4q28-q31 previously identified only in a Chinese Hans population. Both these regions were statistically significant even after correction for multiple testing. A possible reason for the erratic replication of findings could be the large effect of the PSORS1 locus (6p21) masking the effect of other loci involved in psoriasis. To overcome this problem, we suggest that future studies condition on the effect of the PSORS1 locus.
Keyword
- Asian Continental Ancestry Group
- genetics
- Chromosomes
- Human
- Pair 4
- Chromosomes
- Human
- Pair 6
- European Continental Ancestry Group
- genetics
- Genetic Predisposition to Disease
- Genome
- Human
- Humans
- Linkage (Genetics)
- Psoriasis
- genetics
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Sagoo, Gurdeep S
-
Tazi-Ahnini, Rac ...
-
Barker, Jonathan ...
-
Elder, James T
-
Nair, Rajan P
-
Samuelsson, Lena ...
-
show more...
-
Traupe, Heiko
-
Trembath, Richar ...
-
Robinson, Darren ...
-
Iles, Mark M
-
show less...
- Articles in the publication
-
The Journal of i ...
- By the university
-
University of Gothenburg