Search: onr:"swepub:oai:gup.ub.gu.se/61854" >
Voluntary chronic e...
Voluntary chronic exercise augments in vivo natural immunity in rats.
-
- Jonsdottir, Ingibjörg H, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology
-
- Asea, Alexzander, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology
-
- Hoffmann, P (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology
-
show more...
-
- Dahlgren, Ulf, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin,Institute of Laboratory Medicine
-
Andersson, B (author)
-
- Hellstrand, Kristoffer, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology
-
Thorén, Peter (author)
-
show less...
-
(creator_code:org_t)
- 1996
- 1996
- English.
-
In: Journal of applied physiology (Bethesda, Md. : 1985). - 8750-7587. ; 80:5, s. 1799-803
- Related links:
-
https://gup.ub.gu.se...
Abstract
Subject headings
Close
- The effect of chronic voluntary exercise on the immune response was studied in spontaneously hypertensive rats. Exercise consisted of voluntary running in wheels for 5 wk, and the mean running distance was 4.2 km/24 h. In vivo cytotoxicity was measured as clearance of injected 51Cr-labeled YAC-1 lymphoma cells from the lungs. The clearance of YAC-1 cells in vivo was significantly increased in runners compared with sedentary controls (P < 0.001). The total number of mononuclear cells in the spleen was significantly decreased in runners compared with controls. Analysis of splenic lymphocyte phenotypes revealed a significantly increased fraction of OX52+/CD5- natural killer cells in runners compared with sedentary controls. In contrast to changes in natural immunity, immunoglobulins G and M levels in serum, the antibody response to antigen in vivo, and the proliferation of splenic T cells in vitro were unchanged. Our data suggest that chronic voluntary exercise augments natural cytotoxicity mechanisms in vivo, whereas splenic T-cell proliferation and the antibody-mediated immune response remain unchanged.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Animals
- Immunoglobulin G
- metabolism
- Immunoglobulin M
- metabolism
- Lymphoma
- metabolism
- Motor Activity
- physiology
- Physical Conditioning
- Animal
- Rats
- Rats
- Inbred SHR
- Spleen
- metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database