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Effects on rat thal...
Effects on rat thalamic proteome by acute and subchronic MK-801-treatment.
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- Paulson, Linda, 1971 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences
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Martin, Peter (author)
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Ljung, Elisabeth (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences
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- Davidsson, Pia, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences
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(creator_code:org_t)
- Elsevier BV, 2004
- 2004
- English.
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In: European journal of pharmacology. - : Elsevier BV. - 0014-2999. ; 505:1-3, s. 103-9
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Since the symptoms of intoxication with non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists closely mimic symptoms in patients with schizophrenia, [+]-5-methyl-10,11-dihydro-5H-dibenzo-[a,d]-cycloheptene-5,10-iminehydrogenmaleate (MK-801)-treated rodents are often used as a model for schizophrenia. In most studies, acute injections of MK-801 to rats have been used, but in some studies, longer periods of treatment have been performed. In our previous work, alterations in mRNA/protein expression were screened in the cerebral cortex of MK-801 treated rats. Different proteins were altered in different treatment courses of MK-801. The main objective of the present study was to evaluate different treatment periods of treatment with MK-801 in rats as a model for schizophrenia. Thalamus proteins from treated (acute, six and 12 days) and control rats were analyzed with two-dimensional gel electrophoresis and mass spectrometry. Our results show that different treatment times of MK-801 to rats give different biochemical results. Therefore, it is important to use the same treatment time in studies that will be compared.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Animals
- Dizocilpine Maleate
- pharmacology
- Dose-Response Relationship
- Drug
- Electrophoresis
- Gel
- Two-Dimensional
- Male
- Proteome
- analysis
- Rats
- Rats
- Sprague-Dawley
- Spectrometry
- Mass
- Matrix-Assisted Laser Desorption-Ionization
- Thalamus
- drug effects
- metabolism
- Time Factors
Publication and Content Type
- ref (subject category)
- art (subject category)
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