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Nicotinamide does not influence cytokines or exhaled NO in human experimental endotoxaemia.

Soop, A (author)
Albert, J. (author)
Karolinska Institutet
Weitzberg, E (author)
Karolinska Institutet
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Bengtsson, Anders, 1954 (author)
Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård,Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care
Nilsson, C-G (author)
Sollevi, A (author)
Karolinska Institutet
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 (creator_code:org_t)
Oxford University Press (OUP), 2004
2004
English.
In: Clinical and experimental immunology. - : Oxford University Press (OUP). - 0009-9104 .- 1365-2249. ; 135:1, s. 114-8
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • This study examined the hypothesis that nicotinamide could attenuate endotoxin-induced inflammatory responses in humans as indicated by levels of cytokines and nitric oxide. Ten healthy male volunteers participated in a randomised, double-blind, cross-over design with regard to the effects of nicotinamide. The volunteers received orally 4 g nicotinamide or placebo at 14 h and at 2 h preceding the experiment (total dose of 8 g). Endotoxin (E. coli, 2 ng/kg), was administered intravenously. Blood samples and haemodynamic data were collected prior to and up to 6 h after the endotoxin infusion. Orally exhaled NO was measured hourly. Following endotoxin, body temperature increased from baseline 36.3 +/- 0.09 degrees C to a maximum of 38.0 +/- 0.1 degrees C for all (mean +/- SEM, P < 0.001) and heart rate increased from 59 +/- 1.9 to 87.0 +/- 2.6 beats/min after 3 h (mean +/- SEM, P < 0.001). Endotoxin challenge also markedly elevated the TNF-alpha, IL-6, IL-8 and IL-10 concentrations (P < 0.001 versus baseline for all) during the study period. Orally exhaled NO also increased (P < 0.01) compared to baseline. Nicotinamide treatment did not influence the patterns of cytokine and NO response to endotoxin. In conclusion, there was no effect on the inflammatory parameters by oral nicotinamide at a dose of 8 g, limiting the potential use of this agent for anti-inflammatory purpose in man.

Keyword

Adult
Anti-Inflammatory Agents
Non-Steroidal
therapeutic use
Breath Tests
methods
Cross-Over Studies
Cytokines
biosynthesis
Double-Blind Method
Endotoxemia
immunology
prevention & control
Endotoxins
Humans
Male
Niacinamide
therapeutic use
Nitric Oxide
metabolism

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art (subject category)

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