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  • Jensen, EvaGothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård,Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care (author)

Influence of two different perfusion systems on inflammatory response in pediatric heart surgery.

  • Article/chapterEnglish2003

Publisher, publication year, extent ...

  • 2003

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/62956
  • https://gup.ub.gu.se/publication/62956URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: This study tests the hypothesis that a cardiopulmonary bypass system that combines complete heparin-coating, a centrifugal pump, and a closed circuit in comparison with a conventional system (uncoated system, roller pump, and hard shell venous reservoir) attenuates the inflammatory response in pediatric heart surgery. METHODS: In a prospective randomized controlled clinical study 40 consecutive children weighing 10 kg or less were included and divided into two groups. Concentrations of complement proteins (C3a, sC5b-9, C4d, and Bb), granulocyte degranulation products (polymorphonuclear [PMN] elastase), and proinflammatory cytokines (tumor necrosis factor [TNF]-alpha, interleukin [IL]-6, and IL-8) were measured. RESULTS: C3a and sC5b-9 concentrations were lower (C3a, p < 0.001; sC5b-9, p = 0.01) in the combined (heparin-coated/centrifugal pump/closed reservoir) group, the peak values being 58% and 37% of conventional group values. The Bb- and C4d-fragment values indicated activation of the complement system through the alternative pathway in both groups. PMN elastase concentrations were lower (p = 0.02) in the combined group, the peak values being 43% of conventional group values. There were no significant intergroup differences regarding TNF-alpha, IL-6, or IL-8 concentrations. CONCLUSIONS: The use of a fully heparin-coated system, a centrifugal pump, and a closed circuit during CPB in children (10 kg or less) leads to a lower degree of complement activation and PMN elastase release compared with a conventional system.

Subject headings and genre

  • Adolescent
  • Cardiopulmonary Bypass
  • instrumentation
  • Child
  • Child
  • Preschool
  • Coated Materials
  • Biocompatible
  • Complement Activation
  • immunology
  • Equipment Design
  • Female
  • Heart Defects
  • Congenital
  • surgery
  • Heparin
  • Humans
  • Infant
  • Inflammation Mediators
  • blood
  • Interleukin-6
  • blood
  • Interleukin-8
  • blood
  • Leukocyte Elastase
  • blood
  • Male
  • Postoperative Complications
  • immunology
  • prevention & control
  • Systemic Inflammatory Response Syndrome
  • immunology
  • prevention & control
  • Tumor Necrosis Factor-alpha
  • metabolism

Added entries (persons, corporate bodies, meetings, titles ...)

  • Andréasson, SvenerikGothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna,Institute of Surgical Sciences(Swepub:gu)xasvei (author)
  • Bengtsson, Anders,1954Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård,Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care(Swepub:gu)xbeand (author)
  • Berggren, Håkan,1951Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute(Swepub:gu)xbergh (author)
  • Ekroth, Rolf,1944Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute(Swepub:gu)xekrro (author)
  • Lindholm, LenaGothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute (author)
  • Ouchterlony, JohnGothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna,Institute of Surgical Sciences(Swepub:gu)xoucjo (author)
  • Göteborgs universitetInstitutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård (creator_code:org_t)

Related titles

  • In:The Annals of thoracic surgery75:3, s. 919-250003-4975

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