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Hormone replacement...
Hormone replacement therapy, body mass index and asthma in perimenopausal women: a cross sectional survey
- Article/chapterEnglish2006
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LIBRIS-ID:oai:gup.ub.gu.se/63351
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https://gup.ub.gu.se/publication/63351URI
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Subject category:art swepub-publicationtype
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BACKGROUND: Hormone replacement therapy (HRT) and obesity both appear to increase the risk of asthma. A study was undertaken to investigate the association of HRT with asthma and hay fever in a population of perimenopausal women, focusing on a possible interaction with body mass index (BMI). METHODS: A postal questionnaire was sent to population based samples in Denmark, Estonia, Iceland, Norway, and Sweden in 1999-2001, and 8588 women aged 25-54 years responded (77%). Pregnant women, women using oral contraceptives, and women <46 years were excluded. Analyses included 2206 women aged 46-54 years of which 884 were menopausal and 540 used HRT. Stratified analyses by BMI in tertiles were performed. RESULTS: HRT was associated with an increased risk for asthma (OR 1.57 (95% CI 1.07 to 2.30)), wheeze (OR 1.60 (95% CI 1.22 to 2.10)), and hay fever (OR 1.48 (95% CI 1.15 to 1.90)). The associations with asthma and wheeze were significantly stronger among women with BMI in the lower tertile (asthma OR 2.41 (95% CI 1.21 to 4.77); wheeze OR 2.04 (95% CI 1.23 to 3.36)) than in heavier women (asthma: p(interaction) = 0.030; wheeze: p(interaction) = 0.042). Increasing BMI was associated with more asthma (OR 1.08 (95% CI 1.05 to 1.12) per kg/m(2)). This effect was only found in women not taking HRT (OR 1.10 (95% CI 1.05 to 1.14) per kg/m(2)); no such association was detected in HRT users (OR 1.00 (95% CI 0.92 to 1.08) per kg/m(2)) (p(interaction) = 0.046). Menopause was not significantly associated with asthma, wheeze, or hay fever. CONCLUSIONS: In perimenopausal women there is an interaction between HRT and BMI in the effects on asthma. Lean women who were HRT users had as high a risk for asthma as overweight women not taking HRT. It is suggested that HRT and overweight increase the risk of asthma through partly common pathways.
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Svanes, C.
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Björnsson, E. H.
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Franklin, K.
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Gislason, D.
(author)
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Gislason, T.
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Gulsvik, A.
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Janson, C.
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Jögi, R.
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Kiserud, T.
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Norbäck, D.
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Nyström, L.
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Torén, Kjell,1952Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, School of Public Health and Community Medicine,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xtorkj
(author)
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Wentzel-Larsen, T.
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Omenaas, E.
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Göteborgs universitetInstitutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
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Gomez Real, F.
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Svanes, C.
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Björnsson, E. H.
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Franklin, K.
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Gislason, D.
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Gislason, T.
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Gulsvik, A.
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Janson, C.
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Jögi, R.
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Kiserud, T.
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Norbäck, D.
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Nyström, L.
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Torén, Kjell, 19 ...
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Wentzel-Larsen, ...
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Omenaas, E.
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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University of Gothenburg