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Effects of gender a...
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Améen, Caroline,1975Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Wallenberglaboratoriet,Institute of Physiology and Pharmacology, Dept of Physiology,Wallenberg Laboratory
(author)
Effects of gender and GH secretory pattern on sterol regulatory element-binding protein-1c and its target genes in rat liver.
- Article/chapterEnglish2004
Publisher, publication year, extent ...
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American Physiological Society,2004
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/64451
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https://gup.ub.gu.se/publication/64451URI
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https://doi.org/10.1152/ajpendo.00059.2004DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1958007URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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We investigated whether the sexually dimorphic secretory pattern of growth hormone (GH) in the rat regulates hepatic gene expression of sterol regulatory element-binding protein-1c (SREBP-1c) and its target genes. SREBP-1c, fatty acid synthase (FAS), and glycerol-3-phosphate acyltransferase (GPAT) mRNA were more abundant in female than in male livers, whereas acetyl-CoA carboxylase-1 (ACC1) and stearoyl-CoA desaturase-1 (SCD-1) were similarly expressed in both sexes. Hypophysectomized female rats were given GH as a continuous infusion or as two daily injections for 7 days to mimic the female- and male-specific GH secretory patterns, respectively. The female pattern of GH administration increased the expression of SREBP-1c, ACC1, FAS, SCD-1, and GPAT mRNA, whereas the male pattern of GH administration increased only SCD-1 mRNA. FAS and SCD-1 protein levels were regulated in a similar manner by GH. Incubation of primary rat hepatocytes with GH increased SCD-1 mRNA levels and decreased FAS and GPAT mRNA levels but had no effect on SREBP-1c mRNA. GH decreased hepatic liver X receptor-alpha (LXRalpha) mRNA levels both in vivo and in vitro. Feminization of the GH plasma pattern in male rats by administration of GH as a continuous infusion decreased insulin sensitivity and increased expression of FAS and GPAT mRNA but had no effect on SREBP-1c, ACC1, SCD-1, or LXRalpha mRNA. In conclusion, FAS and GPAT are specifically upregulated by the female secretory pattern of GH. This regulation is not a direct effect of GH on hepatocytes and does not involve changed expression of SREBP-1c or LXRalpha mRNA but is associated with decreased insulin sensitivity.
Subject headings and genre
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MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
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MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
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Acetyl-CoA Carboxylase
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genetics
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Animals
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Antigens
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CD95
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genetics
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CCAAT-Enhancer-Binding Proteins
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genetics
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metabolism
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Cells
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Cultured
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DNA-Binding Proteins
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genetics
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metabolism
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Female
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Glycerol-3-Phosphate O-Acyltransferase
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genetics
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Growth Hormone
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blood
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pharmacology
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secretion
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Hepatocytes
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metabolism
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Insulin Resistance
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genetics
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Lipids
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biosynthesis
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Liver
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metabolism
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Male
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RNA
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Messenger
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metabolism
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Rats
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Rats
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Sprague-Dawley
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Receptors
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Cytoplasmic and Nuclear
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genetics
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Sex Characteristics
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Stearoyl-CoA Desaturase
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genetics
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Sterol Regulatory Element Binding Protein 1
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Transcription Factors
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genetics
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metabolism
Added entries (persons, corporate bodies, meetings, titles ...)
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Lindén, Daniel,1971Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
(author)
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Larsson, Britt-Mari,1960Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xlarbr
(author)
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Mode, AgnetaKarolinska Institutet
(author)
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Holmäng, Agneta,1959Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xholag
(author)
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Oscarsson, Jan,1960Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Wallenberglaboratoriet,Institute of Physiology and Pharmacology, Dept of Physiology,Wallenberg Laboratory(Swepub:gu)xoscja
(author)
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Göteborgs universitetInstitutionen för fysiologi och farmakologi, Avdelningen för fysiologi
(creator_code:org_t)
Related titles
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In:American journal of physiology. Endocrinology and metabolism: American Physiological Society287:60193-18491522-1555
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