Search: onr:"swepub:oai:gup.ub.gu.se/65924" > No human tryptophan...
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000 | 04274naa a2200721 4500 | |
001 | oai:gup.ub.gu.se/65924 | |
003 | SwePub | |
008 | 240528s2006 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/659242 URI |
024 | 7 | a https://doi.org/10.1016/j.biopsych.2005.12.0142 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Delorme, Richard4 aut |
245 | 1 0 | a No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjects. |
264 | 1 | b Elsevier BV,c 2006 |
520 | a BACKGROUND: It was recently reported that a rare functional variant, R441H, in the human tryptophan hydroxylase-2 gene (hTPH2) could represent an important risk factor for unipolar major depression (UP) since it was originally found in 10% of UP patients (vs. 1.4% in control subjects). METHODS: We explored the occurrence of this variation in patients with affective disorders (n = 646), autism spectrum disorders (n = 224), and obsessive-compulsive disorder (OCD) (n = 201); in healthy volunteers with no psychiatric disorders (n = 246); and in an ethnic panel of control individuals from North Africa, Sub-Saharan Africa, India, China, and Sweden (n = 277). RESULTS: Surprisingly, we did not observe the R441H variant in any of the individuals screened (3188 independent chromosomes). CONCLUSIONS: Our results do not confirm the role of the R441H mutation of the hTPH2 gene in the susceptibility to UP. The absence of the variant from a large cohort of psychiatric patients and control subjects suggests that the findings reported in the original study could be due to a genotyping error or to stratification of the initial population reported. Additional data by other groups should contribute to the clarification of the discrepancy between our results and those previous published. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
653 | a Adult | |
653 | a Alleles | |
653 | a Chromosomes | |
653 | a Genetics | |
653 | a Cohort Studies | |
653 | a Female | |
653 | a Gene Frequency | |
653 | a Humans | |
653 | a Male | |
653 | a Mental Disorders | |
653 | a Genetics | |
653 | a Middle Aged | |
653 | a Mutation | |
653 | a Genetics | |
653 | a Polymorphism | |
653 | a Single Nucleotide | |
653 | a Genetics | |
653 | a Tryptophan Hydroxylase | |
653 | a Genetics | |
700 | 1 | a Durand, Christelle M4 aut |
700 | 1 | a Betancur, Catalina4 aut |
700 | 1 | a Wagner, Michael4 aut |
700 | 1 | a Ruhrmann, Stephan4 aut |
700 | 1 | a Grabe, Hans-Juergen4 aut |
700 | 1 | a Nygren, Gudrun,d 1957u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xnygrg |
700 | 1 | a Gillberg, Christopher,d 1950u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xgilch |
700 | 1 | a Leboyer, Marion4 aut |
700 | 1 | a Bourgeron, Thomas4 aut |
700 | 1 | a Courtet, Philippe4 aut |
700 | 1 | a Jollant, Fabrice4 aut |
700 | 1 | a Buresi, Catherine4 aut |
700 | 1 | a Aubry, Jean-Michel4 aut |
700 | 1 | a Baud, Patrick4 aut |
700 | 1 | a Bondolfi, Guido4 aut |
700 | 1 | a Bertschy, Gilles4 aut |
700 | 1 | a Perroud, Nader4 aut |
700 | 1 | a Malafosse, Alain4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Biological Psychiatryd : Elsevier BVg 60:2, s. 202-203q 60:2<202-203x 0006-3223 |
856 | 4 | u https://www.hal.inserm.fr/inserm-00124742/file/Delorme_TPH2_Biol_Psychiatry_2006.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/65924 |
856 | 4 8 | u https://doi.org/10.1016/j.biopsych.2005.12.014 |
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