Asperger syndrome: familial and pre- and perinatal factors.

• OBJECTIVE: Study familial and pre- and perinatal factors in Asperger Syndrome (AS). METHODS: One hundred boys with AS had their records reviewed. "Pathogenetic subgroups" were defined according to presence of medical syndromes/chromosomal abnormalities, indices of familiality, and pre- and perinatal risk factors predisposing to brain damage. RESULTS: No major index of pathogenetic factors was found in 13%, a syndrome/chromosomal abnormality in 8%, pre- or perinatal risk 13%, combined pre- or perinatal risk and family history in 11%, and family history only in 55%. COMMENT: About 50% of all boys with AS have a paternal family history of autism spectrum disorder. Pre- and perinatal risks appear to be important in about 25% of cases.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Keyword

Adolescent

Asperger Syndrome

Diagnosis

Etiology

Genetics

Child of Impaired Parents

Statistics & numerical data

Chromosome Aberrations

Diagnostic and Statistical Manual of Mental Disorders

Female

Humans

Male

Medical Records

Perinatology

Pregnancy

Pregnancy Complications

Wechsler Scales

Publication and Content Type

ref (subject category)

art (subject category)