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SUMO4 M55V polymorp...
SUMO4 M55V polymorphism affects susceptibility to type I diabetes in HLA DR3- and DR4-positive Swedish patients
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- Sedimbi, S. K. (author)
- Karolinska Institutet
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- Luo, X. R. (author)
- Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
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- Sanjeevi, C. B. (author)
- Karolinska Institutet
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Lernmark, Ake (author)
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- Landin-Olsson, Mona (author)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Arnqvist, H. (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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Björck, E. (author)
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Nyström, L. (author)
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Ohlson, L. O. (author)
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Schersten, B. (author)
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Östman, J. (author)
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Aili, M. (author)
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Baath, L. E. (author)
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Carlsson, E. (author)
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Edenwall, H. (author)
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- Forsander, Gun, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Granström, B. W. (author)
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Gustavsson, I. (author)
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Hanas, R. (author)
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Hellenberg, L. (author)
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Hellgren, H. (author)
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Holmberg, E. (author)
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Hornell, H. (author)
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Ivarsson, S. A. (author)
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Johansson, C. (author)
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Jonsell, G. (author)
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Kockum, K. (author)
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Lindblad, B. (author)
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Lindh, A. (author)
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- Ludvigsson, Johnny (author)
- Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping
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Myrdal, U. (author)
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Neiderud, J. (author)
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Segnestam, K. (author)
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Sjöblad, S. (author)
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Skogsberg, L. (author)
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Strömberg, L. (author)
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Stahle, U. (author)
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Thalme, B. (author)
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Tullus, K. (author)
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- Tuvemo, Torsten (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/Gustafsson
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Wallensteen, M. (author)
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- Westphal, Otto, 1935 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Dahlquist, Gisela (author)
- Umeå universitet,Pediatrik
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- Aman, J. (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forksning/Gustafsson
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(creator_code:org_t)
- 2007-06-07
- 2007
- English.
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In: Genes Immun. - : Springer Science and Business Media LLC. - 1466-4879 .- 1476-5470. ; 8:6, s. 518-21
- Related links:
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- SUMO4 M55V, located in IDDM5, has been a focus for debate because of its association to type I diabetes (TIDM) in Asians but not in Caucasians. The current study aims to test the significance of M55V association to TIDM in a large cohort of Swedish Caucasians, and to test whether M55V is associated in those carrying human leukocyte antigen (HLA) class II molecules. A total of 673 TIDM patients and 535 age- and sex-matched healthy controls were included in the study. PCR-RFLP was performed to identify the genotype and allele variations. Our data suggest that SUMO4 M55V is not associated with susceptibility to TIDM by itself. When we stratified our patients and controls based on heterozygosity for HLA-DR3/DR4 and SUMO4 genotypes, we found that presence of SUMO4 GG increased further the relative risk conferred by HLA-DR3/DR4 to TIDM, whereas SUMO4 AA decreased the risk. From the current study, we conclude that SUMO4 M55V is associated with TIDM in association with high-risk HLA-DR3 and DR4, but not by itself.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Adolescent
- Adult
- Alleles
- Case-Control Studies
- Child
- Child
- Preschool
- Cohort Studies
- Diabetes Mellitus
- Type 1/*genetics/immunology
- Female
- Genetic Predisposition to Disease
- Genotype
- HLA-DR3 Antigen/*genetics/immunology
- HLA-DR4 Antigen/*genetics/immunology
- Haplotypes
- Humans
- Infant
- Infant
- Newborn
- Male
- Polymorphism
- Single Nucleotide
- Small Ubiquitin-Related Modifier Proteins/*genetics/immunology
- Sweden
- Adolescent
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Sedimbi, S. K.
-
Luo, X. R.
-
Sanjeevi, C. B.
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Lernmark, Ake
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Landin-Olsson, M ...
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Arnqvist, H.
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show more...
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Björck, E.
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Nyström, L.
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Ohlson, L. O.
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Schersten, B.
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Östman, J.
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Aili, M.
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Baath, L. E.
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Carlsson, E.
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Edenwall, H.
-
Forsander, Gun, ...
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Granström, B. W.
-
Gustavsson, I.
-
Hanas, R.
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Hellenberg, L.
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Hellgren, H.
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Holmberg, E.
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Hornell, H.
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Ivarsson, S. A.
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Johansson, C.
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Jonsell, G.
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Kockum, K.
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Lindblad, B.
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Lindh, A.
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Ludvigsson, John ...
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Myrdal, U.
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Neiderud, J.
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Segnestam, K.
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Sjöblad, S.
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Skogsberg, L.
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Strömberg, L.
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Stahle, U.
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Thalme, B.
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Tullus, K.
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Tuvemo, Torsten
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Wallensteen, M.
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Westphal, Otto, ...
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Dahlquist, Gisel ...
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Aman, J.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Genes Immun
- By the university
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University of Gothenburg
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Umeå University
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Uppsala University
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Lund University
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Linköping University
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Karolinska Institutet