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Astrocyte intermedi...
Astrocyte intermediate filaments in CNS pathologies and regeneration.
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- Pekny, Milos, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry
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- Pekna, Marcela, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry
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(creator_code:org_t)
- 2004-10-19
- 2004
- English.
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In: The Journal of pathology. - : Wiley. - 0022-3417. ; 204:4, s. 428-37
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Abstract
Subject headings
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- Astroglial cells are the most abundant cells in the mammalian central nervous system (CNS), yet our knowledge about their function in health and disease has been limited. This review focuses on the recent work addressing the function of intermediate filaments in astroglial cells under severe mechanical or osmotic stress, in hypoxia, and in brain and spinal cord injury. Recent data show that when astrocyte intermediate filaments are genetically ablated in mice, reactive gliosis is attenuated and the course of several CNS pathologies is altered, while the signs of CNS regeneration become more prominent. GFAP is the principal astrocyte intermediate filament protein and dominant mutations in the GFAP gene have been shown to lead to Alexander disease, a fatal neurodegenerative condition in humans.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Alexander Disease
- genetics
- Astrocytes
- metabolism
- Brain Injuries
- physiopathology
- Cell Movement
- physiology
- Central Nervous System Diseases
- metabolism
- physiopathology
- Cytoskeleton
- metabolism
- Glial Fibrillary Acidic Protein
- genetics
- Humans
- Intermediate Filaments
- metabolism
- Nerve Regeneration
- physiology
- Osmosis
- physiology
- Retinal Vessels
- pathology
- Spinal Cord Injuries
- physiopathology
- Stress
- Mechanical
Publication and Content Type
- ref (subject category)
- for (subject category)
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