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Age-dependent sensi...
Age-dependent sensitivity of the developing brain to irradiation is correlated with the number and vulnerability of progenitor cells
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Fukuda, A. (author)
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Fukuda, H. (author)
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- Swanpalmer, John, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för radiofysik,Institute of Selected Clinical Sciences, Department of Radiation Physics
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- Hertzman, Sven (author)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för radiofysik,Institute of Selected Clinical Sciences, Department of Radiation Physics
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- Lannering, Birgitta, 1948 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics
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- Marky, Ildiko, 1940 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics
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- Björk-Eriksson, Thomas, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för onkologi,Institute of Selected Clinical Sciences, Department of Oncology
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- Blomgren, Klas, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute for the Health of Women and Children, Dept of Paediatrics,Institute of Physiology and Pharmacology, Dept of Physiology
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(creator_code:org_t)
- 2005
- 2005
- English.
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In: J Neurochem. ; 92:3, s. 569-84
- Related links:
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https://gup.ub.gu.se...
Abstract
Subject headings
Close
- In a newly established model of unilateral, irradiation (IR)-induced injury we compared the outcome after IR to the immature and juvenile brain, using rats at postnatal days 9 or 23, respectively. We demonstrate that (i) the immature brains contained more progenitors in the subventricular zone (SVZ) and subgranular zone (SGZ) compared with the juvenile brains; (ii) cellular injury, as judged by activation of caspase 3 and p53, as well as nitrotyrosine formation, was more pronounced in the SVZ and SGZ in the immature brains 6 h after IR; (iii) the number of progenitor and immature cells in the SVZ and SGZ decreased 6 h and 7 days post-IR, corresponding to acute and subacute effects in humans, respectively, these effects were more pronounced in immature brains; (iv) myelination was impaired after IR at both ages, and much more pronounced after IR to immature brains; (v) the IR-induced changes remained significant for at least 10 weeks, corresponding to late effects in humans, and were most pronounced after IR to immature brains. It appears that IR induces both an acute loss of progenitors through apoptosis and a perturbed microenvironment incompatible with normal proliferation and differentiation, and that this is more pronounced in the immature brain.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Age Factors
- Animals
- Antigens
- Differentiation/biosynthesis
- Brain/*growth & development/pathology/*radiation effects
- Caspases/metabolism
- Cell Count
- Dentate Gyrus/growth & development/pathology/radiation effects
- Disease Models
- Animal
- Female
- Lateral Ventricles/growth & development/pathology/radiation effects
- Laterality/radiation effects
- Male
- Myelin Sheath/metabolism/pathology
- Particle Accelerators
- Radiation Injuries
- Experimental/*metabolism/pathology
- Radiation Tolerance/*physiology
- Rats
- Rats
- Wistar
- Research Support
- Non-U.S. Gov't
- Stem Cells/pathology/*radiation effects
- Tumor Suppressor Protein p53/metabolism
- Tyrosine/*analogs & derivatives/metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Fukuda, A.
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Fukuda, H.
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Swanpalmer, John ...
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Hertzman, Sven
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Lannering, Birgi ...
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Marky, Ildiko, 1 ...
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show more...
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Björk-Eriksson, ...
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Blomgren, Klas, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
- Articles in the publication
- J Neurochem
- By the university
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University of Gothenburg