Search: onr:"swepub:oai:gup.ub.gu.se/68325" >
Mechanisms of virus...
Mechanisms of virus-induced asthma exacerbations: state-of-the-art. A GA2LEN and InterAirways document.
-
Papadopoulos, N G (author)
-
Xepapadaki, P (author)
-
Mallia, P (author)
-
show more...
-
Brusselle, G (author)
-
Watelet, J-B (author)
-
Xatzipsalti, M (author)
-
Foteinos, G (author)
-
van Drunen, C M (author)
-
Fokkens, W J (author)
-
D'Ambrosio, C (author)
-
Bonini, S (author)
-
- Bossios, Apostolos, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
-
- Lötvall, Jan, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
-
van Cauwenberge, P (author)
-
Holgate, S T (author)
-
Canonica, G W (author)
-
Szczeklik, A (author)
-
Rohde, G (author)
-
Kimpen, J (author)
-
Pitk?ranta, A (author)
-
M?kel?, M (author)
-
Chanez, P (author)
-
Ring, J (author)
-
Johnston, S L (author)
-
show less...
-
(creator_code:org_t)
- Wiley, 2007
- 2007
- English.
-
In: Allergy. - : Wiley. - 0105-4538 .- 1398-9995. ; 62:5, s. 457-70
- Related links:
-
https://europepmc.or...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Viral infections of the respiratory tract are the most common precipitants of acute asthma exacerbations. Exacerbations are only poorly responsive to current asthma therapies and new approaches to therapy are needed. Viruses, most frequently human rhinoviruses (RV), infect the airway epithelium, generate local and systemic immune responses, as well as neural responses, inducing inflammation and airway hyperresponsiveness. Using in vitro and in vivo experimental models the role of various proinflammatory or anti-inflammatory mediators, antiviral responses and molecular pathways that lead from infection to symptoms has been partly unravelled. In particular, mechanisms of susceptibility to viral infection have been identified and the bronchial epithelium appeared to be a key player. Nevertheless, additional understanding of the integration between the diverse elements of the antiviral response, especially in the context of allergic airway inflammation, as well as the interactions between viral infections and other stimuli that affect airway inflammation and responsiveness may lead to novel strategies in treating and/or preventing asthma exacerbations. This review presents the current knowledge and highlights areas in need of further research.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Animals
- Asthma
- immunology
- pathology
- physiopathology
- virology
- Humans
- Picornaviridae Infections
- immunology
- pathology
- physiopathology
- virology
Publication and Content Type
- ref (subject category)
- for (subject category)
Find in a library
-
Allergy
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Papadopoulos, N ...
-
Xepapadaki, P
-
Mallia, P
-
Brusselle, G
-
Watelet, J-B
-
Xatzipsalti, M
-
show more...
-
Foteinos, G
-
van Drunen, C M
-
Fokkens, W J
-
D'Ambrosio, C
-
Bonini, S
-
Bossios, Apostol ...
-
Lötvall, Jan, 19 ...
-
van Cauwenberge, ...
-
Holgate, S T
-
Canonica, G W
-
Szczeklik, A
-
Rohde, G
-
Kimpen, J
-
Pitk?ranta, A
-
M?kel?, M
-
Chanez, P
-
Ring, J
-
Johnston, S L
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Microbiology in ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
- Articles in the publication
-
Allergy
- By the university
-
University of Gothenburg