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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04485naa a2201009 4500 | |
| 001 | oai:gup.ub.gu.se/75210 | |
| 003 | SwePub | |
| 008 | 240528s2005 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/752102 URI |
| 024 | 7 | a https://doi.org/10.1172/JCI227102 DOI |
| 024 | 7 | a https://doi.org/10.1172/JCI2005227102 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Greenhalgh, Christopher J4 aut |
| 245 | 1 0 | a SOCS2 negatively regulates growth hormone action in vitro and in vivo. |
| 264 | 1 | c 2005 |
| 520 | a Mice deficient in SOCS2 display an excessive growth phenotype characterized by a 30-50% increase in mature body size. Here we show that the SOCS2-/- phenotype is dependent upon the presence of endogenous growth hormone (GH) and that treatment with exogenous GH induced excessive growth in mice lacking both endogenous GH and SOCS2. This was reflected in terms of overall body weight, body and bone lengths, and the weight of internal organs and tissues. A heightened response to GH was also measured by examining GH-responsive genes expressed in the liver after exogenous GH administration. To further understand the link between SOCS2 and the GH-signaling cascade, we investigated the nature of these interactions using structure/function and biochemical interaction studies. Analysis of the 3 structural motifs of the SOCS2 molecule revealed that each plays a crucial role in SOCS2 function, with the conserved SOCS-box motif being essential for all inhibitory function. SOCS2 was found to bind 2 phosphorylated tyrosines on the GH receptor, and mutational analysis of these amino acids showed that both were essential for SOCS2 function. Together, the data provide clear evidence that SOCS2 is a negative regulator of GH signaling. | |
| 653 | a Amino Acid Motifs | |
| 653 | a genetics | |
| 653 | a Animals | |
| 653 | a Body Weight | |
| 653 | a drug effects | |
| 653 | a genetics | |
| 653 | a physiology | |
| 653 | a DNA-Binding Proteins | |
| 653 | a genetics | |
| 653 | a metabolism | |
| 653 | a Gene Expression Regulation | |
| 653 | a genetics | |
| 653 | a physiology | |
| 653 | a Growth Hormone | |
| 653 | a administration & dosage | |
| 653 | a genetics | |
| 653 | a physiology | |
| 653 | a Insulin-Like Growth Factor I | |
| 653 | a physiology | |
| 653 | a Liver | |
| 653 | a metabolism | |
| 653 | a pathology | |
| 653 | a Mice | |
| 653 | a Mice | |
| 653 | a Knockout | |
| 653 | a Phosphorylation | |
| 653 | a Protein Binding | |
| 653 | a genetics | |
| 653 | a physiology | |
| 653 | a Receptors | |
| 653 | a Somatotropin | |
| 653 | a genetics | |
| 653 | a metabolism | |
| 653 | a Repressor Proteins | |
| 653 | a genetics | |
| 653 | a metabolism | |
| 653 | a Signal Transduction | |
| 653 | a drug effects | |
| 653 | a genetics | |
| 653 | a physiology | |
| 653 | a Suppressor of Cytokine Signaling Proteins | |
| 653 | a Trans-Activators | |
| 653 | a genetics | |
| 653 | a metabolism | |
| 653 | a Tyrosine | |
| 653 | a metabolism | |
| 700 | 1 | a Rico-Bautista, Elizabeth4 aut |
| 700 | 1 | a Lorentzon, Mattias,d 1970u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine4 aut0 (Swepub:gu)xlomat |
| 700 | 1 | a Thaus, Anne L4 aut |
| 700 | 1 | a Morgan, Phillip O4 aut |
| 700 | 1 | a Willson, Tracy A4 aut |
| 700 | 1 | a Zervoudakis, Panagiota4 aut |
| 700 | 1 | a Metcalf, Donald4 aut |
| 700 | 1 | a Street, Ian4 aut |
| 700 | 1 | a Nicola, Nicos A4 aut |
| 700 | 1 | a Nash, Andrew D4 aut |
| 700 | 1 | a Fabri, Louis J4 aut |
| 700 | 1 | a Norstedt, Gunnar4 aut |
| 700 | 1 | a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine4 aut0 (Swepub:gu)xohlcl |
| 700 | 1 | a Flores-Morales, Amilcar4 aut |
| 700 | 1 | a Alexander, Warren S4 aut |
| 700 | 1 | a Hilton, Douglas J4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för invärtesmedicin4 org |
| 773 | 0 | t The Journal of clinical investigationg 115:2, s. 397-406q 115:2<397-406x 0021-9738 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/75210 |
| 856 | 4 8 | u https://doi.org/10.1172/JCI22710 |
| 856 | 4 8 | u https://doi.org/10.1172/JCI200522710 |
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