Search: onr:"swepub:oai:gup.ub.gu.se/75320" >
On the site and mec...
-
Jansson, John-Olov,1954Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
(author)
On the site and mechanism of action of the anti-obesity effects of interleukin-6.
- Article/chapterEnglish2003
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/75320
-
https://gup.ub.gu.se/publication/75320URI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
We conducted an experimental study examining the site and mechanism of action of the anti-obesity effect of interleukin-6 (IL-6) in mice and rats. We used dual energy X-ray absorptiometry (DEXA) and computerized tomography to investigate the body composition of mice with knockout of the IL-6 gene and wild-type control mice. Rats were treated with IL-6 or vehicle through intracerebroventricular (ICV) cannulae. Energy expenditure was measured as oxygen consumption by indirect calorimetry in metabolic chambers. Results showed that the mice lacking IL-6 increased in body weight compared with wild-type mice from 6 months of age onward, although there was no marked difference in food intake between the pre-obese IL-6 knockout mice and the wild-type mice. IL-6 given as a single ICV injection to rats stimulated oxygen consumption; whereas, the same doses were ineffective when given peripherally. Chronic ICV IL-6 treatment decreased body weight and fat mass in rodents. Administration of IL-6 may decrease fat mass in mice and rats by stimulating energy expenditure at the CNS level, possibly in the hypothalamus.
Subject headings and genre
-
Adipose Tissue
-
drug effects
-
Animals
-
Anti-Obesity Agents
-
pharmacology
-
Blood Glucose
-
metabolism
-
Body Weight
-
drug effects
-
Brain
-
drug effects
-
Energy Metabolism
-
drug effects
-
Injections
-
Intraventricular
-
Interleukin-6
-
pharmacology
-
physiology
-
Mice
-
Mice
-
Knockout
-
Obesity
-
drug therapy
-
metabolism
-
Oxygen Consumption
-
drug effects
-
Rats
Added entries (persons, corporate bodies, meetings, titles ...)
-
Wallenius, Kristina,1973Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
(author)
-
Wernstedt, Ingrid,1978Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism(Swepub:gu)xwerni
(author)
-
Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xohlcl
(author)
-
Dickson, Suzanne L.,1966Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology(Swepub:gu)xdicsu
(author)
-
Wallenius, Ville,1970Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xwalvi
(author)
-
Göteborgs universitetInstitutionen för invärtesmedicin
(creator_code:org_t)
Related titles
-
In:Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society13 Suppl A1096-6374
Internet link
Find in a library
To the university's database